Kidney Function After Spleen Removal Surgery in People With Liver Cirrhosis
Follows kidney function for 2 years after spleen removal in adults with cirrhosis.
Plain-language title generated from the registry record
Registry title: Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)
Key facts
- Where
- Yangzhou, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with liver cirrhosis, an enlarged spleen and hypersplenism who are having a laparoscopic splenectomy. It follows their kidney function for 2 years.
- Age
- 18 to 80 years
- Sex
- Men and women
- Disease stage
- Liver cirrhosis with an enlarged spleen and hypersplenism. Liver function must be Child-Pugh Class A or B.
- Earlier treatment
- No past bleeding from portal hypertension (bleeding from veins in the gullet or stomach).
Main reasons for not taking part
- Child-Pugh Class C liver cirrhosis
- Primary kidney disease or past acute kidney injury (AKI)
- Previous abdominal surgery that makes laparoscopic splenectomy unsafe
- Severe heart, lung or brain blood vessel problems, cancer, or primary blood disorders
- Pregnancy or breastfeeding
Read by machine on 13 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07585773, who can take part
Where in China
- Clinical Medical College of Yangzhou UniversityYangzhou, ChinaContact: Guo-Qing Jiang, MDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Northern Jiangsu People's Hospital
- Trial code
- NCT07585773
- Record updated
- 18 May 2026
- Original description
Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome). Laparoscopic splenectomy is commonly used to treat splenomegaly and hypersplenism in these patients, but its impact on kidney function over 2 years is unclear. This study will follow patients undergoing laparoscopic splenectomy to measure changes in kidney function before and after surgery, identify risk factors for kidney damage and whether laparoscopic splenectomy can improve kidney function in the long term, and help improve care to protect kidney function in cirrhotic patients .Read full original descriptionShow less
A Prospective, Single-Center, Observational Cohort Study to Evaluate the Short-Term and Long-Term (2-Year) Effects of Laparoscopic Splenectomy on Renal Function in Patients With Liver Cirrhosis, Splenomegaly and Hypersplenism
Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome). Laparoscopic splenectomy is commonly used to treat splenomegaly and hypersplenism in these patients, but its impact on kidney function over 2 years is unclear. This study will follow patients undergoing laparoscopic splenectomy to measure changes in kidney function before and after surgery, identify risk factors for kidney damage and whether laparoscopic splenectomy can improve kidney function in the long term, and help improve care to protect kidney function in cirrhotic patients .
Inclusion: Confirmed diagnosis of liver cirrhosis (clinical, laboratory, imaging); Splenomegaly and hypersplenism; No history of portal hypertension bleeding (esophageal and gastric variceal bleeding ); Age 18-80 years, male or female; Child-Pugh Class A or B liver function; No history of primary renal disease or acute kidney injury (AKI); Signed written informed consent; Ability to complete 24-month follow-up.
Exclusion: Previous abdominal surgery precluding safe laparoscopic splenectomy; Cirrhotic complications (portal hypertension bleeding, hepatic encephalopathy, refractory ascites) within 1 month before surgery; Primary renal diseases (glomerulonephritis, polycystic kidney disease, chronic pyelonephritis, etc.); Severe cardiac, pulmonary, cerebrovascular dysfunction; malignant tumors; primary hematological disorders; Child-Pugh Class C liver cirrhosis; Pregnancy or lactation; Poor compliance, inability to complete follow-up.