A Study of IN026 in Participants With Refractory Gout
Key facts
- Where
- Wuhan, ChinaSee the site
- Phase
- Phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07587684, who can take part
Where in China
- Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, ChinaContact: Huazhong University of Science and Technology Union Hospital, Tongji Medical College,Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Trial code
- NCT07587684
- Record updated
- 31 July 2026
- Original description
The goal of this clinical study is to learn if IN026 Injection is safe and works to lower uric acid levels in adults with refractory gout (gout that does not respond well to standard treatments). The main questions it aims to answer are:Read full original descriptionShow less
A Clinical Study on the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of IN026 in the Treatment of Refractory Gout
The goal of this clinical study is to learn if IN026 Injection is safe and works to lower uric acid levels in adults with refractory gout (gout that does not respond well to standard treatments). The main questions it aims to answer are:
* What medical problems do participants have when taking IN026, such as changes in vital signs, blood tests, or heart rhythm? * How does the body absorb, process, and respond to IN026, and does it trigger an immune reaction? * Does IN026 lower uric acid levels in the blood and reduce tophi?
Investigator will start with lower doses of IN026 and slowly increase the dose to find the well-tolerated dose.
Participants will:
* Receive IN026 through an intravenous (IV) drip into a vein at a set dose. * Complete a screening period of up to 4 weeks, followed by treatment and check-ups for up to 20 weeks. * Have blood and urine samples taken at set times to check safety and how the body responds to IN026.
Inclusion: Can voluntarily sign the informed consent form (ICF) and comply with ICF and study protocol requirements; Male or female, 18-75 years old (inclusive) at screening; Meet 2015 ACR/EULAR gout classification criteria, in the intercritical phase of gout or acute flare resolved ≥2 weeks at screening; Serum uric acid ≥420 μmol/L (7 mg/dl) at screening; Meet the definition of refractory gout (poor uric acid control accompanied by severe gout symptoms).
Exclusion: Gout secondary to radiotherapy/chemotherapy, lead poisoning, organ transplantation, tumor, etc. at screening/baseline; Participants with a history of any of the following: serious cardiovascular diseases within 6 months prior to screening; or serious diseases of the digestive, respiratory, urinary, musculoskeletal, neuropsychiatric, hematological, or immune systems within 3 months prior to screening; Participants who have received medications that may affect endpoint assessment, such as other urate-lowering therapies, mRNA-LNP vaccine, PEGylated drugs and uricase agents; Participation in other clinical trials within 30 days prior to screening; Positive HBsAg; HCV antibody positive is excluded except those with sustained HCV-RNA negativity after standard treatment; HIV antibody positive; active syphilis; Presence of chronic liver diseases including active hepatitis, cirrhosis and alcoholic liver disease; Uncontrolled or untreated hypertension at screening; History of severe allergy, or known allergy to IN026 or its components; Glucose-6-phosphate dehydrogenase (G6PD) deficiency history, or G6PD level below normal lower limit; Rheumatoid arthritis, infectious/septic arthritis, or other acute inflammatory arthritis at screening/baseline; Prolonged QTcF at screening; Participants with poor compliance, or those deemed otherwise unsuitable for this study by the investigator.