Macrophage Activity in Heart and Leg Artery Disease
Compares immune cells in artery plaques and blood in adults with artery disease.
Plain-language title generated from the registry record
Registry title: Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease
Key facts
- Where
- Cotignola, ItalySee the site
Where in Italy
- Maria Cecilia HospitalCotignola, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Maria Cecilia Hospital
- Trial code
- NCT07588295
- Record updated
- 14 May 2026
- Original description
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages.Read full original descriptionShow less
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease: the LAST-COP Study
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages.
This study aims to evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions, and to correlate these findings with the distribution of circulating monocyte subpopulations.
Inclusion: Patients with chronic coronary artery disease; Patients with no-ST elevation acute coronary syndrome; Patients with chronic claudication (Rutherford II-III); Patients with critical limb ischemia (Rutherford IV-V).
Exclusion: Use of antinflammatory drugs; Recent surgical procedures; Severe valve disease; Advanced heart failure; Advanced liver disease; Chronic inflammatory or autoimmune disease; Acute infection; Severe renal dysfunction.