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A lifestyle program for people living with multiple sclerosis

Tests a 12-week program of food, exercise, sleep and stress in adults with MS.

Key facts

Who runs it
New York University Abu Dhabi
Where
Abu Dhabi, United Arab EmiratesSee the site
Trial code
Registry title
Healthy Eating and Active Living for People Living With Multiple Sclerosis (HEAL MS): A Lifestyle Program for People With Multiple Sclerosis
Status
Not yet recruiting
People taking part
30 people, planned
Started
15 Apr 2026
Expected to end
15 Nov 2027
Type of study
Interventional
Treatments tested
  • Multi-Domain Lifestyle Intervention
Record updated
15 May 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 18 to 50 who have multiple sclerosis (MS) and can walk, and who can join a 12-week lifestyle program with online exercise sessions.

Age
18 to 50 years
Sex
All sexes can join.
Disease stage
Confirmed MS diagnosis (McDonald criteria). EDSS score of 6.5 or lower, meaning the person can walk with or without help.
Earlier treatment
On a stable disease-modifying therapy for at least 3 months.

Main reasons for not taking part

  • Significant cognitive impairment that affects using the app or understanding the program
  • MS relapse within the past 3 months
  • Pregnancy or planned pregnancy
  • Unmanaged psychiatric disorders
  • Other immune-related, chronic inflammatory or metabolic diseases

The registry criteria, word for word

Show all 15 criteriaShow less

Who can take part

  • Confirmed MS diagnosis (McDonald criteria)
  • EDSS score ≤ 6.5 (i.e., ambulatory with or without assistance)
  • Stable disease-modifying therapy for ≥ 3 months
  • Age 18-50
  • Proficiency in English or Arabic
  • Clearance to participate in a structured exercise program
  • Ability to walk, sit and stand independently, and perform light-to-moderate movement patterns, even with modifications
  • Ability and digital literacy to interact with the bilingual HEAL MS mobile app and
  • Access to a computer for participation in online sessions

Who cannot take part

  • Concurrent enrollment in another lifestyle intervention
  • Significant cognitive impairment affecting app use and comprehension of the intervention
  • Unmanaged psychiatric disorders
  • Other immune-related or chronic inflammatory or metabolic diseases
  • MS relapse within the past 3 months
  • Pregnancy or planned pregnancy

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 50 years old?

Where in United Arab Emirates

  • Yas ClinicAbu Dhabi, United Arab EmiratesContact: Lev Brylev, MD, PhDNo longer taking part

About the trial

What the trial wants to find out

The goal of this clinical trial is to learn whether a structured lifestyle program can improve health and wellbeing in people living with multiple sclerosis (MS). The program focuses on four areas: nutrition, physical activity, sleep, and stress management. The study will also examine how lifestyle changes affect biological markers related to inflammation, metabolism, and immune function.

Read full original descriptionShow less

The main questions the study aims to answer are:

Can a 12-week lifestyle program improve fatigue, physical function, sleep, and quality of life in people with MS? Do lifestyle changes influence biological markers related to inflammation, metabolism, and mitochondrial function?

Participants will first complete a 12-week observation period to measure their usual lifestyle and health. After this, they will take part in the 12-week HEAL MS lifestyle program.

Participants will:

Attend four assessment visits at Yas Clinic (baseline, before the intervention, after the intervention, and three months later) Participate in two supervised online exercise sessions per week during the 12-week program Follow a structured nutrition plan, with meals provided during the first two weeks Use a mobile application to log daily habits related to exercise, nutrition, sleep, and stress Complete questionnaires and physical tests and provide blood, saliva, and stool samples during assessment visits

Researchers will analyze these data to understand whether lifestyle interventions can support symptom management and overall health in people living with MS.

The group in the trial

  • HEAL MS Lifestyle InterventionTreatment being tested

    Participants first complete a 12-week observation period during which they maintain their usual lifestyle. This is followed by a 12-week HEAL MS lifestyle intervention targeting four domains: adaptive movement, anti-inflammatory nutrition, sleep optimization, and stress regulation. The movement component includes twice-weekly supervised online group exercise sessions using scalable functional exercises. The nutrition component provides personalized meal plans with two weeks of meal delivery to support adherence. Sleep and stress modules include circadian hygiene strategies, breathwork, and mindfulness practices. Participants track daily behaviors, wellbeing, and optional wearable data through a bilingual mobile application. Assessments including blood sampling, body composition, functional fitness testing, and questionnaires are conducted at baseline, pre-intervention, post-intervention, and three months post-intervention.

    Treatment: Multi-Domain Lifestyle Intervention

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
HEAL MS: A Culturally Adapted Lifestyle Medicine Intervention Targeting Metabolic and Immune Dysregulation in Multiple Sclerosis Using Multi-Omics Profiling
Plain-language title
A lifestyle program for people living with multiple sclerosisGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT07589062, who can take part
Record updated
15 May 2026