GENicular Nerve Block in KNEE Arthroplasty
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07589127, who can take part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Helse Møre og Romsdal HF
- Trial code
- NCT07589127
- Record updated
- 21 August 2026
- Original description
The goal of this clinical trial is to learn whether a preoperative genicular nerve block (GNB) can reduce pain after knee replacement surgery in adults with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA). It will also assess whether this treatment can reduce opioid use and improve recovery.Read full original descriptionShow less
GENicular Nerve Block in KNEE Arthroplasty - The GENKNEE Trial
The goal of this clinical trial is to learn whether a preoperative genicular nerve block (GNB) can reduce pain after knee replacement surgery in adults with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA). It will also assess whether this treatment can reduce opioid use and improve recovery.
The main questions it aims to answer are:
* Does a preoperative GNB reduce pain during movement 24 hours after surgery compared with placebo? * Does it reduce opioid consumption and improve physical activity and functional outcomes after surgery?
Researchers will compare patients receiving a GNB to patients receiving a placebo injection to see if the nerve block improves postoperative pain and recovery.
Participants will:
* Be randomly assigned to receive either a GNB or a placebo injection before surgery * Undergo standard knee replacement surgery and postoperative care * Report pain levels at regular intervals after surgery * Complete questionnaires on function, quality of life, and recovery * Wear an activity monitor to measure physical activity after surgery * Attend follow-up assessments at 1 week, 1 month, and 3 months
Inclusion: Symptomatic knee OA grade II-IV according to the Kellgren-Lawrence classification system scheduled for primary total knee arthroplasty; American Society of Anesthesiologists (ASA) Physical Status grade I-III; Able to provide written informed consent; Able to undergo surgery under spinal anesthesia.
Exclusion: Revision surgery; Patients scheduled for day care surgery; Allergy to local anesthetics; Cognitive impairment; Younger than 18 or older than 80 years; ASA physical status IV; Chronic opioid use (> 3 months); Coagulopathy; Inability to comply with study procedures.