How blood sugar and fat levels relate to artery stiffness and blood pressure
Looks at metabolic markers, artery stiffness and blood pressure in adults having routine monitoring.
Plain-language title generated from the registry record
Registry title: Cf-PWV and TyG Index Study
Key facts
- Where
- São José do Rio Preto, BrazilSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07589374, who can take part
Where in Brazil
- Medicine School of São José do Rio PretoSão José do Rio Preto, BrazilNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hospital de Base
- Trial code
- NCT07589374
- Record updated
- 22 May 2026
- Original description
This study aims to investigate how metabolic health is related to arterial stiffness and daily blood pressure patterns. High blood pressure is one of the leading causes of heart disease worldwide, but cardiovascular risk is not determined only by average blood pressure values. Changes in blood vessel structure and metabolic function also play an important role in the development of cardiovascular disease.Read full original descriptionShow less
Correlation Between Carotid-Femoral Pulse Wave Velocity and Triglyceride-Glucose Index and Its Derived Metrics
This study aims to investigate how metabolic health is related to arterial stiffness and daily blood pressure patterns. High blood pressure is one of the leading causes of heart disease worldwide, but cardiovascular risk is not determined only by average blood pressure values. Changes in blood vessel structure and metabolic function also play an important role in the development of cardiovascular disease.
Arterial stiffness reflects how flexible or rigid the arteries are. It can be measured using carotid-femoral pulse wave velocity (cf-PWV), which is considered a reliable and widely used method to assess vascular health. Increased arterial stiffness is associated with aging and higher cardiovascular risk.
At the same time, metabolic factors such as insulin resistance and central obesity are strongly linked to vascular damage. The triglyceride-glucose (TyG) index is a simple measure derived from routine blood tests and has been shown to reflect insulin resistance. Additional derived indices that combine TyG with body measurements (such as waist circumference and body mass index) may provide an even more comprehensive evaluation of metabolic risk.
Another important aspect of cardiovascular regulation is how blood pressure changes throughout the day. Blood pressure naturally rises in the morning after waking, a phenomenon known as the morning blood pressure surge. When this increase is excessive, it has been associated with a higher risk of cardiovascular events such as stroke and heart attack.
This study will evaluate the relationship between metabolic indices, arterial stiffness, and morning blood pressure patterns in adults undergoing ambulatory blood pressure monitoring as part of routine clinical care. The study will include both previously collected data and new participants evaluated using standardized methods.
No additional interventions will be performed, and all data will be collected as part of routine clinical evaluation. The results of this study may help improve cardiovascular risk assessment by integrating simple metabolic markers with vascular measurements and daily blood pressure behavior, potentially allowing earlier identification of individuals at higher risk.
Inclusion: Adults aged 18 to 65 years; Both sexes; Referred for ambulatory blood pressure monitoring (ABPM) as part of routine clinical evaluation; Not receiving antihypertensive medication at the time of assessment; Availability of valid 24-hour ABPM data; Availability of carotid-femoral pulse wave velocity (cf-PWV) measurement; Availability of fasting laboratory data, including glucose and triglycerides, for calculation of the triglyceride-glucose (TyG) index; Ability and willingness to provide written informed consent (for prospectively recruited participants).
Exclusion: Use of antihypertensive medication at the time of evaluation; Cardiac arrhythmias that may interfere with accurate blood pressure or pulse wave velocity measurements; Presence of severe vascular disease or conditions affecting arterial waveform assessment; Missing essential clinical, laboratory, or hemodynamic data required for the primary analysis; Invalid or poor-quality ambulatory blood pressure monitoring (ABPM) recordings; Inability to obtain reliable carotid-femoral pulse wave velocity (cf-PWV) measurements; Pregnancy; Refusal or inability to provide informed consent (for prospectively recruited participants).