Brain stimulation to improve metabolism in people with stable bipolar disorder and obesity
Tests a brain stimulation method in adults with stable bipolar disorder and obesity.
Plain-language title generated from the registry record
Registry title: Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disorder Comorbid With Obesity
Key facts
- Where
- Hangzhou, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Source: NCT07589647, who can take part
Where in China
- First Affiliated Hospital of Zhejiang UniversityHangzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- First Affiliated Hospital of Zhejiang University
- Trial code
- NCT07589647
- Record updated
- 27 May 2026
- Original description
This study aims to stabilize the patients with bipolar disorder (BD) comorbid with obesity in the stable phase by using temporal interference stimulation (TIS ) intervention. It intends to investigate the changes in key metabolic molecules such as GLP-1 circadian rhythm, and further explore the molecular mechanism of their metabolic disorders.Read full original descriptionShow less
Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disordercomorbid With Obesity
This study aims to stabilize the patients with bipolar disorder (BD) comorbid with obesity in the stable phase by using temporal interference stimulation (TIS ) intervention. It intends to investigate the changes in key metabolic molecules such as GLP-1 circadian rhythm, and further explore the molecular mechanism of their metabolic disorders.
Inclusion: Both biological parents are of Han ethnicity; Age range: 18 to 45 years old, gender not restricted; Meets the clinical diagnostic criteria for bipolar disorder as stipulated in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); Body Mass Index (BMI) ≥ 28 kg/m2, or for males, waist circumference ≥ 90 cm and for females, waist circumference ≥ 85 cm; HAMD-24 score < 7 points, YMRS score < 5 points; All included researchers and their family members have given informed consent for this study.
Exclusion: Those who consumed food or microecological preparations containing probiotics, prebiotics, etc. within one week before enrollment, and had a history of respiratory, urinary, digestive system infections and antibiotic use within one month before enrollment; Individuals with other DSM-5 spectrum disorders; Mental disorders caused by substance abuse (such as alcohol, drugs, etc.), and those with severe physical illnesses; Those who cannot complete MRI examinations due to special conditions such as having metal implants or pacemakers in their bodies; 221/5000; Those currently having serious suicidal thoughts or behaviors, or those with severe agitation; Those who cannot follow medical advice for treatment, or those without guardians; Pregnant or lactating women, or those planning to become pregnant.