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Natural History of Central and Mixed Sleep Apneas Followed by Maxillomandibular Advancement for Obstructive Sleep Apnea

Key facts

Who runs it
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Where
Amsterdam, NetherlandsSee the site
Trial code
Status
Not yet recruiting
People taking part
60 people, planned
Starts
1 Dec 2026
Expected to end
31 Dec 2027
Type of study
Observational
Record updated
19 May 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

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Who can take part

  • Adults aged 18 years or older
  • Mild to severe OSA as determined by a polysomnography (PSG) preoperatively
  • Completion of MMA for OSA treatment
  • Subjects with preoperative and postoperative PSG
  • Patients who are present with MMA treatment-related central apneas postoperatively

Who cannot take part

  • Previous history of orthognathic surgery
  • Patients who underwent other adjunctive procedures at the time of MMA (e.g., multi-piece Le Fort osteotomy, TMJ reconstruction)
  • Cleft palate and syndromic patients

Where in Netherlands

  • Department of Oral and Maxillofacial SurgeryAmsterdam, NetherlandsContact: Dr. HoNo longer taking part

About the trial

What the trial wants to find out

The goal of this observational prospective cohort study is to learn about the natural course of central and mixed sleep apneas that develop after maxillomandibular advancement (MMA) surgery for obstructive sleep apnea (OSA) in adult patients.

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The main question it aims to answer is:

Do central and mixed apneas resolve, partially resolve, or persist in the long term after MMA?

Participants will:

Undergo a first postoperative polysomnography (PSG) at 3-6 months after MMA (part of standard care).

Be invited into the study if central/mixed apneas are detected (CMAI% >25%). Undergo a second PSG at least 12 months after MMA (extra study procedure)

The group in the trial

  • Adults with OSA who developed central and/or mixed sleep apneas after MMA

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Record updated
19 May 2026