Pregabalin Phonophoresis and MET for Knee Osteoarthritis
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Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 60 years old?
Source: NCT07598474, who can take part
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- How often do I need to come in, and for how long each time?
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Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Faisalabad
- Trial code
- NCT07598474
- Record updated
- 20 May 2026
- Original description
Knee osteoarthritis (OA) is a common condition causing pain, stiffness, and difficulty walking. Many patients with advanced (Grade III) knee OA also experience neuropathic pain - burning, tingling, or electric shock sensations - which is harder to treat with standard physiotherapy. Oral pregabalin works for neuropathic pain but causes side effects like dizziness and drowsiness. This study tests whether delivering pregabalin through the skin using ultrasound (phonophoresis), combined with calf muscle stretching (Muscle Energy Technique), can reduce nerve pain and improve walking better than ultrasound alone.Read full original descriptionShow less
Evaluating the Combined Efficacy of Pregabalin-Encapsulated Hydrogel Phonophoresis Along With Gastrocnemius Muscle Energy Technique on Neuropathic Pain and Mobility in Grade III Knee Osteoarthritis
Knee osteoarthritis (OA) is a common condition causing pain, stiffness, and difficulty walking. Many patients with advanced (Grade III) knee OA also experience neuropathic pain - burning, tingling, or electric shock sensations - which is harder to treat with standard physiotherapy. Oral pregabalin works for neuropathic pain but causes side effects like dizziness and drowsiness. This study tests whether delivering pregabalin through the skin using ultrasound (phonophoresis), combined with calf muscle stretching (Muscle Energy Technique), can reduce nerve pain and improve walking better than ultrasound alone.
Inclusion: Diagnosed Grade III knee osteoarthritis confirmed by Kellgren-Lawrence grading scale (radiograph within past 12 months or newly obtained); Neuropathic pain component confirmed by DN-4 questionnaire (score ≥4); Age between 40 and 70 years inclusive; Both male and female participants; Unilateral or bilateral knee involvement (if bilateral, the more symptomatic knee selected for assessment and treatment); Willing and able to provide written informed consent; Available to attend 4 sessions per week for 4 consecutive weeks (total 16 sessions); Able to understand and follow verbal instructions (for MET).
Exclusion: Metal implants (including knee replacement), pacemaker, or other electronic implant (contraindications for ultrasound); Received intra-articular knee injection (corticosteroid or hyaluronic acid) within the last 3 months; Previous knee replacement surgery (partial or total); Concurrent participation in another interventional study; Diabetic neuropathy (diagnosed or DN-4 score attributable to diabetes rather than knee OA); Active skin lesions, wounds, infections, or dermatitis on the knee or calf; Known allergy or hypersensitivity to pregabalin, gabapentin, or any gel components; Diagnosis of fibromyalgia, complex regional pain syndrome, or other centralized pain disorder that might confound neuropathic pain assessment; Active malignancy or history of knee malignancy; Deep vein thrombosis or thrombophlebitis in lower limb; Grade I, II, or IV knee osteoarthritis (Kellgren-Lawrence); Aseptic arthritis of knee (rheumatoid, psoriatic, gouty); Any lower extremity deformity (genu varum >15°, genu valgum >15°, fixed flexion deformity >15°); Pregnant or lactating women (ultrasound safety in pregnancy not established for non-obstetric use).