Binge eating, depression and anxiety after two types of weight-loss surgery
Compares sleeve gastrectomy and gastric bypass in adults with severe obesity.
Plain-language title generated from the registry record
Registry title: Binge Eating, Depression and Anxiety Outcomes After Sleeve Gastrectomy Versus Gastric Bypass: A Cohort Study
Key facts
- Where
- Cairo, EgyptSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT07600411, who can take part
Where in Egypt
- Faculty of Medicine Cairo UniversityCairo, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Cairo University
- Trial code
- NCT07600411
- Record updated
- 20 May 2026
- Original description
The goal of this clinical trial is to learn if the type of weight-loss surgery (sleeve gastrectomy or gastric bypass) affects binge eating, depression, and anxiety in adults with severe obesity. The main questions it aims to answer are:Read full original descriptionShow less
Binge Eating, Depression and Anxiety Outcomes Following Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y or One-Anastomosis Gastric Bypass: A Prospective Cohort Study
The goal of this clinical trial is to learn if the type of weight-loss surgery (sleeve gastrectomy or gastric bypass) affects binge eating, depression, and anxiety in adults with severe obesity. The main questions it aims to answer are:
Does sleeve gastrectomy lead to different changes in binge eating compared with gastric bypass?
Does the type of surgery lead to different changes in depression and anxiety symptoms?
Researchers will compare people who have sleeve gastrectomy with those who have gastric bypass to see if there are differences in binge eating, depression, and anxiety levels up to 12 months after surgery.
Participants will:
Complete questionnaires about eating habits, mood, anxiety, general health, and body image before surgery.
Undergo either a sleeve gastrectomy or a gastric bypass operation (both are standard care).
Follow a standard post-surgery diet plan.
Attend follow-up visits at 1 week, 2 weeks, 1 month, and then monthly for 12 months, where they will complete the same questionnaires again.
Inclusion: Age between 18 and 60 years; Body Mass Index (BMI) ≥ 35 kg/m² without comorbidities, OR BMI ≥ 30 kg/m² with at least one obesity-related medical comorbidity (e.g., type 2 diabetes, hypertension, obstructive sleep apnea, dyslipidemia); Patient is generally fit for laparoscopic surgery and general anesthesia as determined by preoperative evaluation; Patient agrees to comply with postoperative lifestyle changes (dietary modifications and follow-up schedule); Willing and able to provide written informed consent.
Exclusion: Contraindication to surgery: American Society of Anesthesiologists (ASA) class IV or higher; History of receiving radiotherapy or chemotherapy for cancer treatment; Previous bariatric surgery (revisional surgery excluded); Active substance use disorder or uncontrolled severe psychiatric illness that would impair ability to comply with study procedures (e.g., active psychosis, severe suicidal ideation); Untreated thyroid disorder (e.g., hypothyroidism or hyperthyroidism); Age < 18 years or > 60 years; Inability or unwillingness to adhere to postoperative lifestyle changes; Pregnant or breastfeeding women (pregnancy test performed preoperatively per institutional protocol).