Nerve Block Before Thyroid Removal Surgery and the Body's Stress Response
Tests a neck nerve block's effect on surgical stress in thyroidectomy patients.
Plain-language title generated from the registry record
Registry title: The Association Between Bilateral Intermediate Cervical Plexus Block During Total Thyroidectomy and Surgical Stress Response
Key facts
- Where
- Zagreb, CroatiaSee the site
- Phase
- Phase 4
Where in Croatia
- University Hospital DubravaZagreb, CroatiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital Dubrava
- Trial code
- NCT07600580
- Record updated
- 16 June 2026
- Original description
The aim of this study is to determine the impact of ultrasound-guided bilateral intermediate cervical plexus block on the surgical stress response in patients undergoing total thyroidectomy, as measured by the concentration of stress and inflammatory biomarkers in the participants' saliva and serum.Read full original descriptionShow less
The Association Between Bilateral Intermediate Cervical Plexus Block and Salivary and Serum Biomarkers of Surgical Stress Response During Total Thyroidectomy
The aim of this study is to determine the impact of ultrasound-guided bilateral intermediate cervical plexus block on the surgical stress response in patients undergoing total thyroidectomy, as measured by the concentration of stress and inflammatory biomarkers in the participants' saliva and serum.
The study will be conducted on 48 subjects divided into two groups of 24: a control group receiving total intravenous anesthesia (TIVA) and an experimental group receiving TIVA combined with a bilateral intermediate cervical plexus block.
Investigators hypothesized that a combination of bilateral intermediate cervical plexus block and total intravenous anesthesia (TIVA) would reduce the surgical stress response, as measured by salivary and blood biomarkers, compared to TIVA alone in patients undergoing total thyroidectomy.
Should the research confirm the hypothesis, it will provide an objective scientific argument for including the block in standard anesthetic protocols for total thyroidectomy surgeries, with the ultimate goal of reducing the surgical stress response and ensuring faster patient recovery.
Inclusion: patienets of both sexes; 18 years of age and older; ASA I or ASA II; euthyroid status; signed informed consent.
Exclusion: hypothyroidism or hyperthyroidism at the time of surgery; additional surgical interventions during the procedure; history of previous neck surgery or radiation; chronic corticosteroid therapy; infection at the block injection site; hypersensitivity or contraindications to the medications used in the study; uncontrolled respiratory disease; diabetes mellitus; autoimmune disease; patients who refuse to sign the informed consent form; presence of substernal goiter; coagulopathy; smokers; pregnant women.