How Removing Extra Fluid Affects Sleep Apnea in Heart Failure
Looks at sleep apnea before and after fluid removal in hospitalized heart failure patients.
Key facts
- Who runs it
- Itshak Amsalem
- Where
- Jerusalem, IsraelSee the site
- Trial code
- Registry title
- The Impact of Volume Overload on Obstructive Sleep Apnea in Patients With Congestive Heart Failure
- Status
- Recruiting
- People taking part
- 50 people, planned
- Started
- 1 Jan 2026
- Expected to end
- Jun 2027
- Type of study
- Observational
- Record updated
- 22 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults in hospital with heart failure and extra fluid in the body who need water pills (diuretics). It studies whether removing fluid improves sleep apnea.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Hospitalized with decompensated heart failure (reduced or preserved ejection fraction) and clear signs of fluid overload, with diuretic treatment clinically needed
- Earlier treatment
- People currently treated with continuous positive airway pressure (CPAP) cannot join
Main reasons for not taking part
- Known central sleep apnea as the main type of sleep breathing problem
- Current treatment with CPAP
- Acute respiratory failure needing mechanical ventilation
- Conditions that stop proper use of the WatchPAT device, such as severe hand or finger injury
- Unstable circulation (hemodynamic instability) or pregnancy
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Adults aged 18 years or older
- Hospitalized with decompensated heart failure and clinical evidence of fluid overload
- Diagnosis of heart failure (reduced or preserved ejection fraction)
- Clinically indicated for diuretic therapy
- Able to undergo sleep apnea assessment using the WatchPAT device
- Able to provide informed consent
Who cannot take part
- Current treatment with continuous positive airway pressure (CPAP)
- Acute respiratory failure requiring mechanical ventilation
- Conditions preventing proper use of the WatchPAT device (e.g., severe hand or finger injury)
- Known central sleep apnea as the predominant sleep-disordered breathing type
- Hemodynamic instability precluding participation
- Pregnancy
Where in Israel
- Shaare Zedek Medical CenterJerusalem, IsraelContact: Itshak Amsalem, MDTaking people
About the trial
What the trial wants to find out
The goal of this observational study is to learn how removing extra fluid from the body (diuresis) affects sleep apnea in adults hospitalized with heart failure.
Read full original descriptionShow less
The main questions it aims to answer are:
Does sleep apnea severity improve after fluid removal? Is the improvement in sleep apnea related to the amount of fluid removed? Do changes in neck size reflect changes in sleep apnea severity?
Participants admitted to the hospital with heart failure and fluid overload will take part in this study.
Participants will:
Use a wearable sleep monitoring device (WatchPAT) on the first night of hospitalization Use the device again after fluid removal, when the treating cardiologist determines that the patient is no longer fluid overloaded Have their neck circumference measured before and after fluid removal Have their weight and fluid balance recorded during hospitalization Have routine blood tests and clinical assessments as part of standard care
Researchers will compare each participant's results before and after fluid removal to see if sleep apnea improves and whether these changes are linked to fluid removal and changes in neck circumference.
The group in the trial
- Adults With Heart Failure Undergoing Diuresis
Adults hospitalized with heart failure and fluid overload who undergo standard diuretic therapy. Participants are evaluated using sleep monitoring (WatchPAT), neck circumference measurements, and clinical assessments before diuresis (on the first night of hospitalization) and after diuresis, when the treating cardiologist determines that the patient is no longer fluid overloaded.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Impact of Volume Overload on Obstructive Sleep Apnea in Patients With Congestive Heart Failure
- Plain-language title
- How Removing Extra Fluid Affects Sleep Apnea in Heart FailureGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 22 May 2026