Brain Stimulation to Help Language Recovery in People With Aphasia After Stroke
Tests magnetic brain stimulation for language problems in adults after a stroke.
Plain-language title generated from the registry record
Registry title: Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe
Key facts
- Where
- Columbia, United StatesSee the site
Where in United States
- McCausland CenterColumbia, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of South Carolina
- Trial code
- NCT07608588
- Record updated
- 29 May 2026
- Original description
This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery. Functional Magnetic Resonance Imaging (fMRI) will provide critical insights into the effects of facilitatory versus inhibitory stimulation on interhemispheric balance. Additionally, this study will generate new data on how lesion localization and brain connectivity influence individual responses to rTMS, explaining variability in treatment efficacy.Read full original descriptionShow less
Recovery From Post-Stroke Aphasia With rTMS Targeting the Anterior Temporal Lobe: Interhemispheric Activation Changes and Lesion-Connectome-Based Predictive Outcomes
This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery. Functional Magnetic Resonance Imaging (fMRI) will provide critical insights into the effects of facilitatory versus inhibitory stimulation on interhemispheric balance. Additionally, this study will generate new data on how lesion localization and brain connectivity influence individual responses to rTMS, explaining variability in treatment efficacy.
Inclusion: Right-handedness (assesed using the Edinburgh Handedness Inventory); Native English speakers; Single left hemispheric stroke; Diagnosis of aphasia and lexicosemantic impairments (e.g., anomia, semantic errors in picture naming or spontaneous speech) confirmed by a Speech and Language Pathologist or Physician.
Exclusion: Contraindications to rTMS (e.g., uncontrolled epilepsy, history of seizures, intracranial ferromagnetic body, cochlear implant, or factors that lower seizure threshold (see Rossi et al., 2021); Stroke involving the left ATL; Severe depression or psychiatric history; Known neurodegenerative disorders; Severely impaired auditory comprehension (WAB Comprehension score of 0 or 1); Major phonological impairments (defined as > 2 errors in non-word repetition of one- and two-syllable items on the PALPA, 2); Contraindication to MRI; Illiteracy; Severe uncorrected visual or hearing impairments.