Lung Airflow and Blood Flow Changes After Angioplasty for Clotted Dialysis Grafts
Watches lung airflow and blood flow after angioplasty in dialysis patients with graft clots.
Plain-language title generated from the registry record
Registry title: Changes in Regional Ventilation-Perfusion Match Following Percutaneous Transluminal Angioplasty for Arteriovenous Graft Thrombosis
Key facts
- Where
- Wuhu, ChinaSee the site
Where in China
- The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)Wuhu, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- First Affiliated Hospital of Wannan Medical College
- Trial code
- NCT07613632
- Record updated
- 29 May 2026
- Original description
Patients with end-stage renal disease (ESRD) often require arteriovenous grafts (AVG) for hemodialysis. AVG thrombosis is a common complication, usually managed by percutaneous transluminal angioplasty (PTA) to restore blood flow. PTA achieves patency by balloon-mediated compression and fragmentation of thrombus. Small thrombus fragments may enter the venous circulation and cause transient pulmonary microembolism, leading to ventilation-perfusion (V/Q) mismatch. This study uses electrical impedance tomography (EIT) to noninvasively monitor short-term changes in regional ventilation and perfusion during and after PTA, exploring the immediate pulmonary physiological consequences of thrombus fragmentation and revascularization in dialysis patients.Read full original descriptionShow less
Changes in Regional Ventilation-Perfusion Match Following Percutaneous Transluminal Angioplasty for Arteriovenous Graft Thrombosis: A Prospective Observation Pilot Study
Patients with end-stage renal disease (ESRD) often require arteriovenous grafts (AVG) for hemodialysis. AVG thrombosis is a common complication, usually managed by percutaneous transluminal angioplasty (PTA) to restore blood flow. PTA achieves patency by balloon-mediated compression and fragmentation of thrombus. Small thrombus fragments may enter the venous circulation and cause transient pulmonary microembolism, leading to ventilation-perfusion (V/Q) mismatch. This study uses electrical impedance tomography (EIT) to noninvasively monitor short-term changes in regional ventilation and perfusion during and after PTA, exploring the immediate pulmonary physiological consequences of thrombus fragmentation and revascularization in dialysis patients.
Inclusion: Age ≥ 18 years; Diagnosis of end-stage renal disease receiving maintenance hemodialysis; Documented AVG thrombosis requiring PTA; Able to cooperate and tolerate EIT monitoring; Provided written informed consent.
Exclusion: Severe respiratory failure incompatible with supine position; Thoracic skin condition or deformity preventing EIT electrode placement; NYHA Class IV heart failure or hemodynamic instability; Acute pulmonary embolism or acute pulmonary edema before procedure; Pregnancy or breastfeeding; Any other circumstance judged unsuitable by investigator.