Tests INCA033989 Against Standard Care in Essential Thrombocythemia
Tests INCA033989 against standard treatment in adults with essential thrombocythemia and a CALR mutation.
Plain-language title generated from the registry record
Registry title: A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia
Key facts
- Where
- Budapest, Debrecen, and Pécs, HungarySee the 3 sites
- Phase
- Phase 3
Where in Hungary
- Semmelweis University-Internal Medicine and HaematologyBudapest, HungaryNot yet recruiting
- Debreceni Egyetem Klinikai KozpontDebrecen, HungaryNot yet recruiting
- University of PecsPécs, HungaryNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Incyte Corporation
- Trial code
- NCT07623200EU 2026-525398-38-00
- Record updated
- 5 November 2026
- Original description
This study is being conducted to evaluate INCA033989 versus best available therapy in participants with essential thrombocythemia and a CALR mutation previously treated with cytoreductive therapy.Read full original descriptionShow less
A Phase 3, Randomized, Open-Label Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia and a CALR Mutation Previously Treated With Cytoreductive Therapy (EXCALIBUR-ET2)
This study is being conducted to evaluate INCA033989 versus best available therapy in participants with essential thrombocythemia and a CALR mutation previously treated with cytoreductive therapy.
Inclusion: Confirmed diagnosis of high-risk ET; Presence of mutCALR; Prior treatment with at least 1 cytoreductive therapy.
Exclusion: Major bleeding or thrombosis within the last 3 months prior to study enrollment; Any prior allogenic or autologous stem-cell transplantation; Unresolved toxicity ≥ Grade 2 from previous therapy except for stable chronic toxicities (Grade 2) not expected to resolve, such as stable Grade 2 peripheral neuropathy; Prior nonhematologic malignancy except for the following: Malignancy treated with curative intent and with no evidence of active disease for more than 2 years before screening. Adequately treated carcinoma in situ without current evidence of disease; Other protocol-defined Inclusion/Exclusion Criteria apply; Presence of any hematologic malignancy other than ET.