Blood BDNF levels and strokes caused by heart clots in ischemic stroke patients
Measures BDNF in blood of adults treated for ischemic stroke.
Key facts
- Who runs it
- Centre Hospitalier Universitaire Dijon
- Where
- Dijon, FranceSee the site
- Trial code
- Registry title
- Association Between Circulating BDNF Levels and Cardioembolic Strokes in Patients Treated for Ischemic Stroke
- Status
- Recruiting
- People taking part
- 150 people, planned
- Started
- 23 Sept 2026
- Expected to end
- Sept 2031
- Type of study
- Observational
- Treatments tested
- Circulating BDNF levels measured via blood sample
- Record updated
- 25 September 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with an acute ischemic stroke confirmed by brain imaging, treated at the Dijon Bourgogne University Hospital stroke unit.
- Age
- 18 years and older
- Sex
- All sexes can join
- Disease stage
- Acute ischemic stroke confirmed by brain imaging (CT or MRI)
Main reasons for not taking part
- Person under guardianship, conservatorship or a judicial safeguard measure
- Pregnant, recently given birth, or breastfeeding woman
- Adult legally incapacitated or unable to give consent
- Minor
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Individuals who provided informed consent
- Diagnosis of acute ischemic stroke confirmed by brain imaging (CT or MRI)
- Patient admitted to the USINV of the Department of General, Vascular, and Degenerative Neurology at the Dijon Bourgogne University Hospital during the inclusion period
- Underwent a combined cardiac and brain CT scan within 24 hours of admission for stroke
Who cannot take part
- A person subject to a legal protective measure (guardianship, conservatorship)
- A person subject to a judicial safeguard measure
- A pregnant woman, a woman who has recently given birth, or a breastfeeding woman
- An adult who is legally incapacitated or unable to give consent,
- A minor
Where in France
- Chu Dijon BourgogneDijon, FranceContact: Yannick BEJOT, PrTaking people
About the trial
What the trial wants to find out
Atrial fibrillation (AF) is associated with serious complications, including embolic strokes, heart failure, and mortality. Disruption of normal blood flow in the atrium, particularly in the context of an endocardium predisposed to thrombosis, increases the risk of thrombus formation. Once dislodged from the atrial cavity and traveling to the cerebral arteries, these thrombi can cause a cardioembolic stroke. The main risk factors for atrial cardiomyopathy (ACM) and AF are metabolic syndrome and aging.
Read full original descriptionShow less
ACM is a condition that is difficult to diagnose because it is not clearly defined, except through histological analysis. Guided by the results of our experimental approaches, the investigators aim to address this challenge by examining ACM through the lens of one of its complications: cardioembolic stroke. BDNF (Brain-Derived Neurotrophic Factor) is a neurotrophic factor involved in inflammatory and metabolic processes that may play a key role in the development of these complications.
This study explores the association between circulating levels of BDNF and the morphological and metabolic characteristics of ACM, as assessed by cardiac and brain imaging studies
The group in the trial
- Patient who has suffered an acute ischemic stroke
Patient diagnosed with acute ischemic stroke based on brain imaging
Treatment: Circulating BDNF levels measured via blood sample
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Association Between Circulating BDNF Levels and Cardioembolic Strokes in Patients Treated for Ischemic Stroke
- Plain-language title
- Blood BDNF levels and strokes caused by heart clots in ischemic stroke patientsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 25 September 2026