Measuring Thigh and Grip Strength in Adults Across Southern Europe
Measures thigh and hand strength in healthy adults and people with lung disease.
Plain-language title generated from the registry record
Registry title: Reference Equations and Normative Data for Isometric Quadriceps and Handgrip Muscles STrength in Southern European Populations - RESTart: a Multicentre Study
Key facts
- Where
- Alcalá de Henares, SpainSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 89 years old?
Source: NCT07628530, who can take part
Where in Spain
- University of AlcaláAlcalá de Henares, SpainNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Alcala
- Trial code
- NCT07628530
- Record updated
- 8 June 2026
- Original description
This observational study aims to learn about peripheral muscle strength in healthy adults and people with chronic respiratory diseases. The study aims to develop reference data for quadriceps muscle strength and handgrip in adults living in Southern Europe and to assess whether these reference data can be used in people with chronic respiratory diseases.Read full original descriptionShow less
Reference Equations and Normative Data for Isometric Quadriceps and Handgrip Muscles STrength in Southern European Populations - RESTart: a Multicentre Study
This observational study aims to learn about peripheral muscle strength in healthy adults and people with chronic respiratory diseases. The study aims to develop reference data for quadriceps muscle strength and handgrip in adults living in Southern Europe and to assess whether these reference data can be used in people with chronic respiratory diseases.
The main questions it aims to answer are:
* What are the normal values for quadriceps and handgrip muscle strength in healthy adults aged 18-89 years living in Spain, Portugal and Italy? * Can the reference values developed in healthy adults be applied to people with chronic respiratory diseases?
Participants will attend one study visit. During this visit, researchers will:
* Measure quadriceps muscle strength and handgrip. * Collect information about age, sex, height, weight and other health characteristics. * Perform simple functional tests related to mobility and physical performance. * Ask participants to complete questionnaires about symptoms, physical activity and health-related quality of life.
Inclusion: Age between 18-89 years; Spanish, Portuguese or Italian, or permanently resident in one of those countries for at least five years; Be community-dwelling (i.e., not hospitalised or institutionalised); Be functionally independent and capable of performing study assessments without assistance or limiting pain; Be able to follow verbal instructions in the local language (Spanish, Portuguese or Italian, as appropriate); Provide written informed consent; Aged 18-89 years; Clinical diagnosis of a chronic respiratory disease (e.g., COPD, interstitial lung disease, asthma, bronchiectasis, cystic fibrosis), confirmed by spirometry or clinical records; Clinically stable (no exacerbation within the past four weeks); Capacity to provide informed consent and complete study procedures.
Exclusion: Recent surgery (e.g., within the past six months) in upper or lower limbs; Systemic corticosteroids use for over one week in the previous six months (i.e., risk of muscle atrophy in type II fibres; or steroid myopathy); Muscle relaxants use during the previous week (i.e., risk of not full muscle activation); Acute or chronic musculoskeletal conditions affecting strength: recent fractures, severe osteoarthrosis, ligament injury, acute tendinitis in hands/knee areas, among others; Neuromuscular disorders: Parkinson, multiple sclerosis, stroke, peripheral neuropathies, among others; Non-communicable diseases affecting strength or functional status: active cancer, any unstable heart diseases; any CRD; active rheumatological diseases, obesity (BMI≥30kg/m2), uncontrolled metabolic diseases, among others (not included: controlled dyslipidaemia or arterial hypertension); Cognitive impairments (e.g., dementia) or psychiatric disorders impairing following instructions; Current smoking; Chronic respiratory disease cohort; Coexisting conditions which meet the exclusion criteria defined for healthy participants, apart from chronic respiratory diseases; Aid devices for walking or compromised functional mobility; Moderate-to-severe pain during the assessment (VAS ≥4); Pregnancy and postpartum (i.e., potential physiological changes which may alter muscle strength); Current requirement for hospitalisation or acute medical management; Severe functional limitation preventing completion of assessments.
Healthy adults cohort.