Cryotherapy Versus Standard Care in Reducing Opioid Consumption After Total Knee Arthroplasty
Key facts
- Where
- Buenos Aires, ArgentinaSee the site
Where in Argentina
- Hospital Italiano de Buenos AiresBuenos Aires, ArgentinaContact: Ivan a Huespe, mdTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Hospital Italiano de Buenos Aires
- Trial code
- NCT07630337
- Record updated
- 5 June 2026
- Original description
The goal of this clinical trial is to learn if compressive cryotherapy can reduce postoperative opioid consumption in patients undergoing primary total knee arthroplasty. It will also evaluate whether compressive cryotherapy improves postoperative recovery compared with standard care using conventional ice application. The main questions it aims to answer are:Read full original descriptionShow less
Efficacy of Cryotherapy Versus Standard Care in Reducing Opioid Consumption After Total Knee Arthroplasty: A Randomized Controlled Trial
The goal of this clinical trial is to learn if compressive cryotherapy can reduce postoperative opioid consumption in patients undergoing primary total knee arthroplasty. It will also evaluate whether compressive cryotherapy improves postoperative recovery compared with standard care using conventional ice application. The main questions it aims to answer are:
Does compressive cryotherapy reduce the total consumption of opioids during the first 7 days after total knee arthroplasty?
Does compressive cryotherapy reduce postoperative pain and improve early recovery compared with standard cryotherapy?
Researchers will compare compressive cryotherapy using the Game Ready® device with standard care using traditional ice packs to determine whether the intervention reduces opioid consumption and improves postoperative outcomes.
Participants will:
Be randomly assigned to receive compressive cryotherapy or standard cryotherapy with ice packs after surgery.
Apply the assigned treatment four times per day during the first 7 postoperative days.
Record daily pain levels using a visual analog scale (VAS) and document opioid consumption in a pain diary.
Attend a follow-up visit on postoperative day 7 for evaluation of knee swelling, hematoma size, and recovery using the QoR-15 questionnaire.
Inclusion: Age between 60 and 80 years; Scheduled to undergo primary total knee arthroplasty for knee osteoarthritis; Ability to understand the study procedures and provide written informed consent.
Exclusion: Vascular disorders affecting the lower limbs; Active knee infection; Revision total knee arthroplasty; Body mass index (BMI) greater than 35 kg/m²; Severe preoperative limitations in knee mobility.