Tests a mapping-guided heart ablation for atrial fibrillation
Tests a personalized ablation guided by unipolar mapping in people with atrial fibrillation.
Plain-language title generated from the registry record
Registry title: Unipolar Voltage Mapping for Personalized Atrial Fibrillation Ablation
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07630857, who can take part
Where in China
- Fuwai HospitalBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- China National Center for Cardiovascular Diseases
- Trial code
- NCT07630857
- Record updated
- 16 June 2026
- Original description
Atrial fibrillation (AF) is a common heart rhythm disorder. While catheter ablation is an effective treatment, many patients still experience AF recurrence after the procedure. One major reason is that the mechanisms that maintain AF are not fully understood. Research suggests that the outer layer of the heart (epicardium) may play an important role in keeping AF going. However, current mapping techniques have limitations in detecting electrical signals from both the inner and outer heart layers.Read full original descriptionShow less
Unipolar Mapping for Personalized Atrial Fibrillation Ablation: An Interventional Study on Arrhythmia Maintenance and Atrial Remodeling
Atrial fibrillation (AF) is a common heart rhythm disorder. While catheter ablation is an effective treatment, many patients still experience AF recurrence after the procedure. One major reason is that the mechanisms that maintain AF are not fully understood. Research suggests that the outer layer of the heart (epicardium) may play an important role in keeping AF going. However, current mapping techniques have limitations in detecting electrical signals from both the inner and outer heart layers.
This study uses a different technique called unipolar voltage mapping, which may more accurately capture electrical signals from both heart layers. Specifically, we focus on a specific type of electrical signal called "QS potential" on unipolar mapping, which reflects breakthrough sites between the inner and outer heart layers.
In this interventional study, participants with AF undergoing catheter ablation will receive personalized ablation guided by unipolar QS-potential mapping. We aim to:
Explore the relationship between unipolar QS-potentials and AF maintenance and atrial remodeling Evaluate the effectiveness of QS-potential guided personalized AF ablation
Inclusion: Age ≥ 18 years and ≤ 80 years; Documented diagnosis of atrial fibrillation (paroxysmal or persistent); Planned to undergo catheter ablation for AF (including patients with recurrent AF after prior ablation); Able and willing to provide written informed consent; Able to complete scheduled follow-up visits (3 months post-ablation).
Exclusion: Participation in another interventional clinical trial within 30 days prior to enrollment; Severe valvular heart disease (moderate to severe mitral stenosis or regurgitation); History of intracardiac thrombus; Active infection or sepsis; Life expectancy < 12 months due to comorbid conditions; Left ventricular ejection fraction < 35%; Contraindication to anticoagulation; Pregnancy or breastfeeding.