How ankle blood pressure changes after walking relate to peripheral arterial disease
Studies how walking affects leg blood flow measures in people with peripheral arterial disease.
Key facts
- Who runs it
- Louisiana State University Health Sciences Center Shreveport
- Where
- Shreveport, United StatesSee the site
- Trial code
- Registry title
- Ankle-Brachial Index Changes Post Exercise and Its Effects on Patient-Centered Outcomes and Gait
- Status
- Not yet recruiting
- People taking part
- 85 people, planned
- Started
- Jun 2026
- Expected to end
- Jan 2028
- Type of study
- Observational
- Record updated
- 9 June 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with peripheral arterial disease (PAD, narrowed leg arteries) or at risk of it. It studies how ankle blood pressure changes after a 6-minute walk.
- Age
- 18 years and older. Over 65 years of age; or 50-64 with one risk factor; or 18-50 with diabetes and one more risk factor; or any age with known artery disease.
- Sex
- All sexes can join.
- Disease stage
- Known PAD or narrowed arteries elsewhere (heart, neck, arm, kidney or gut arteries), or risk factors such as diabetes, smoking, high cholesterol, high blood pressure or family history of PAD.
- Biomarker or test result
- People with noncompressible arteries (ABI >1.4) cannot join.
Main reasons for not taking part
- History of deep vein thrombosis (blood clot in a deep vein) or other reasons arm or ankle pressure cannot be measured
- Lymphedema (swelling) of the arms or legs, past mastectomy, or a current leg ulcer stopping a cuff on the lower leg
- Unable to lie flat for 15 min or to walk for 6 minutes
- Severe heart or lung disease limiting exercise
- No pulse found by Doppler, or unable to give consent
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- individuals over 65 years of age
- individuals aged 50-64 with a risk factor for atherosclerosis including diabetes mellitus, history of smoking, hyperlipidemia, hypertension, or family history of peripheral arterial disease (PAD)
- individuals aged 18-50 with diabetes mellitus and one additional risk factor for atherosclerosis as noted above, or
- individuals with known atherosclerotic disease in another vascular bed including the coronary, carotid, subclavian, renal, or mesenteric artery stenosis, and individuals with known PAD
Who cannot take part
- contraindications to brachial and/or ankle pressure measurement including history of deep vein thrombosis
- history of mastectomy or current leg ulceration preventing placement of a blood pressure cuff around the lower leg
- severe cardiac or pulmonary disease limiting exercise
- lymphedema of the arms or legs
- an inability to lie in a supine position for 15 min
- self-reported inability to walk for 6 minutes
- inability to obtain a Dopplerable pulse
- noncompressible arteries (ABI >1.4)
- those unable to consent
Where in United States
- LSU Health ShreveportShreveport, United StatesContact: Sarah Murnane, PT, DPT, PhD(c)Not yet recruiting
About the trial
What the trial wants to find out
The goal of this observational study or clinical trial is to investigate how exercise can affect different areas of a person's life, especially those people with vascular disease. This is important because exercise can be beneficial for people with vascular disease. The study could include any of the following: those aged 65 years of age and older, between the ages of 50-64 who smokes, has diabetes, high blood pressure, high cholesterol, or has a family member with vascular disease, between the ages of 18-49 with diabetes and one other factor listed above, or those with vascular disease. The main question[s] it aims to answer is if exercise testing can better predict vascular disease.
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The following research questions will be addressed in this study:
1. Does baseline ABI influence the magnitude and recovery trajectory of ABI following an acute bout of exercise across a spectrum of vascular function? 2. What association does exercise-induced ABI changes have on patient-reported outcomes of quality of life and intermittent claudication? 3. Do functional outcomes of gait speed, time to claudication, gait variables related to rest breaks in 6MWT, and walking distance predict the magnitude of exercise-induced ABI reduction?
Participants will :
* complete various questionnaires and a routine screening for vascular disease *walk for 6 minutes at your own pace * additional vascular screening tests will be performed.
The group in the trial
- study participants
baseline ABI
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Exercise-Induced Ankle-Brachial Index Dynamics as a Predictive Marker in Peripheral Arterial Disease
- Plain-language title
- How ankle blood pressure changes after walking relate to peripheral arterial diseaseGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Record updated
- 9 June 2026