Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation
Key facts
- Where
- Seoul, South KoreaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 19 and 100 years old?
Source: NCT07638176, who can take part
Where in South Korea
- Samsung Medical CenterSeoul, South KoreaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Samsung Medical Center
- Trial code
- NCT07638176
- Record updated
- 14 September 2026
- Original description
This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.Read full original descriptionShow less
Effects of Individualized Positive End-expiratory Pressure (PEEP) on Intrinsic PEEP and Stroke Volume During One-lung Ventilation: a Single-center, Randomized Crossover Study
This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.
Inclusion: American Society of Anesthesiologists Physical Status I - III; The Eastern Cooperative Oncology Group Performance Status Grade 0 - 2; Lung resection surgery requiring one-lung ventilation for over 60 minutes; Indication of double-lumen endobronchial tube (female 35 Fr, male 37 Fr); Patient who is diagnosed with intrinsic PEEP during one-lung ventilation.
Exclusion: Emergency surgery; Mechanical ventilation before surgery; Hemodynamic instability before surgery; Surgery requiring cardiopulmonary bypass; Large bullae; Pregnancy, breastfeeding patient; Patient's refusal to participate; No intrinsic PEEP during one-lung ventilation.