Which bacteria cause serious infections in French children with sickle cell disease
Looks back at which bacteria caused serious infections in children with sickle cell disease.
Plain-language title generated from the registry record
Registry title: Epidemiology of Invasive Bacterial Infections in Children With Sickle Cell Disease in France Between 2020 and 2025
Key facts
- Where
- Argenteuil, Aulnay-sous-Bois, Bondy, Bordeaux, Boulogne-Billancourt, Bry-sur-Marne, Cergy-Pontoise, Clamart, Corbeil-Essonnes, Créteil, Fontainebleau, Gonesse, Jossigny, Le Kremlin-Bicêtre, Mantes-la-Jolie, Marseille, Meaux, Melun, Montfermeil, Nantes, Neuilly-sur-Seine, Nice, Orsay, Paris, Poissy, Rambouillet, Saint-Denis, Versailles, and Villeneuve-Saint-Georges, FranceSee the 31 sites
Where in France
- Hôpital Victor Dupouy (CH Argenteuil)Argenteuil, FranceNo longer taking part
- CHI Robert BallangerAulnay-sous-Bois, FranceNo longer taking part
- Hôpital Jean VerdierBondy, FranceNo longer taking part
- Hôpital Pellegrin - Hôpital des EnfantsBordeaux, FranceNo longer taking part
- Hôpital Ambroise-ParéBoulogne-Billancourt, FranceNo longer taking part
- Hôpital Saint CamilleBry-sur-Marne, FranceNo longer taking part
- Hôpital NOVOCergy-Pontoise, FranceNo longer taking part
- Hopital Antoine BeclereClamart, FranceNo longer taking part
- CH Sud FrancilienCorbeil-Essonnes, FranceNo longer taking part
- Chi CreteilCréteil, FranceNo longer taking part
- CH du Sud Seine et MarneFontainebleau, FranceNo longer taking part
- CH GonesseGonesse, FranceNo longer taking part
- GHEF, Site de Marne-la-ValléeJossigny, FranceNo longer taking part
- Hopital BicetreLe Kremlin-Bicêtre, FranceNo longer taking part
- GHT Yvelines NordMantes-la-Jolie, FranceNo longer taking part
- Hopital Nord AP-HMMarseille, FranceNo longer taking part
- GHEF Site de MeauxMeaux, FranceNo longer taking part
- GH Sud Ile-de-FranceMelun, FranceNo longer taking part
- Ghi Le Raincy-MontfermeilMontfermeil, FranceNo longer taking part
- CHU NantesNantes, FranceNo longer taking part
- CH Rives de Seine, Site de Neuilly-sur-SeineNeuilly-sur-Seine, FranceNo longer taking part
- CHU LenvalNice, FranceNo longer taking part
- Hôpital Paris-SaclayOrsay, FranceNo longer taking part
- Hôpital NeckerParis, FranceNo longer taking part
- Hopital Robert DebreParis, FranceNo longer taking part
- Hôpital TrousseauParis, FranceNo longer taking part
- CHI PoissyPoissy, FranceNo longer taking part
- CH RambouilletRambouillet, FranceNo longer taking part
- CH Saint-Denis - Hôpital DelafontaineSaint-Denis, FranceNo longer taking part
- Hôpital André MignotVersailles, FranceNo longer taking part
- Hôpital Intercommunal Villeneuve-St-GeorgesVilleneuve-Saint-Georges, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Trial code
- NCT07639008
- Record updated
- 10 June 2026
- Original description
Children with sickle cell disease are at high risk of invasive bacterial infections, which may lead to serious complications. Preventive measures, including antibiotic prophylaxis and vaccination, have changed the epidemiology of these infections over time. New pneumococcal conjugate vaccines have recently become available, and updated data are needed to better understand which bacteria are currently responsible for invasive infections in this population.Read full original descriptionShow less
Epidemiology of Invasive Bacterial Infections in Children With Sickle Cell Disease in France Between 2020 and 2025
Children with sickle cell disease are at high risk of invasive bacterial infections, which may lead to serious complications. Preventive measures, including antibiotic prophylaxis and vaccination, have changed the epidemiology of these infections over time. New pneumococcal conjugate vaccines have recently become available, and updated data are needed to better understand which bacteria are currently responsible for invasive infections in this population.
The aim of this retrospective study is to describe the bacterial distribution of invasive bacterial infections in children with sickle cell disease in France between 2020 and 2025. The results may help improve knowledge of these infections and guide future prevention strategies, including antibiotic management and vaccination policies.
Inclusion: Children with sickle cell disease aged under 18 years; Hospitalized between January 2020 and December 2025; Hospitalized for an invasive bacterial infection clinically defined as meningitis, pleuropneumonia, osteoarticular infection, or primary bacteremia; Bacterium identified by culture or PCR.
Exclusion: Urinary tract infection; Opposition from the child or his/her parents; Bacterium identified by serology.