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Taking people in United StatesNo phase

VR-Based Cognitive Stimulation Games for Delirium Prevention

Key facts

Who runs it
The Methodist Hospital Research Institute
Where
Houston, United StatesSee the 2 sites
Trial code
Status
Recruiting
People taking part
90 people, planned
Started
24 Apr 2026
Expected to end
1 May 2029
Type of study
Interventional, 3 groups
Treatments tested
  • Virtual Reality Software
  • Virtual Reality movies
  • Nurse led control arm
Record updated
11 June 2026

Who can take part

Age
Up to 65 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 13 criteriaShow less

Who can take part

  • Men and women ≥65 years of age
  • Have a pre-existing diagnosis of cognitive impairment (Montreal Cognitive Assessment Score of 15-24)
  • Elective or emergency major surgery with the expectation of admission to the Intensive Care Unit following the surgery for three days following surgery

Who cannot take part

  • admission for a drug overdose
  • Prolonged intubation after surgery (more than 24 hours)
  • history of severe mental illness
  • history of severe postoperative nausea and vomiting
  • hearing and visual impairment
  • preexisting severe dementia (Montreal Cognitive Assessment Score < 15; and
  • Active suicidal ideation or behavior Screen failure after surgery
  • Pre-existing Intubation and invasive ventilation
  • severe vertigo
  • active delirium at the time of screening for eligibility criteria

Where in United States

  • Houston Methodist HospitalHouston, United StatesContact: Hina Faisal, MDTaking people
  • Houston Methodist Research InsitituteHouston, United StatesContact: Hina Faisal, MD (principal investigator)Taking people

About the trial

What the trial wants to find out

This trial aims to evaluate the feasibility, safety, and acceptability of a virtual reality (VR)-based cognitive stimulation game to reduce postoperative delirium among older surgical patients at high risk due to pre-existing cognitive impairment.

The 3 groups in the trial

  • VR intervention: VR-based cognitive stimulation gamesTreatment being tested

    Participants will engage in interactive, VR-based cognitive stimulation games.

    Treatment: Virtual Reality Software

  • VR Control: watching a movie in VRTreatment being tested

    Participants will watch a non-interactive VR movie experience consisting of educational material.

    Treatment: Virtual Reality movies

  • Nurse control: standard-of-care nurse-led reality orientationTreatment being tested

    Participants will receive standard-of-care, nurse-led reality orientation therapy.

    Treatment: Nurse led control arm

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Virtual Reality-Based Cognitive Stimulation Games for Enhancing Attention and Preventing Delirium in Older Surgical Patients With Cognitive Impairment
Record updated
11 June 2026