Clot-busting drug versus standard artery opening in heart attack when hospital delays are expected
Compares tenecteplase with standard catheter treatment in heart attack patients facing expected treatment delays.
Plain-language title generated from the registry record
Registry title: Reperfusion Approach in Predicted In-hospital Delay for Primary PCI in STEMI
Key facts
- Where
- Moscow, RussiaSee the site
- Phase
- Phase 4
Where in Russia
- National Medical Research Center for Cardiology, Ministry of Health of Russian FederationMoscow, RussiaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
- Trial code
- NCT07641231
- Record updated
- 11 June 2026
- Original description
This study aims at evaluating of the effectiveness of in-hospital thrombolysis for ST-segment elevation myocardial infarction in PCI centers under conditions of predicted in-hospital delay (>60 min after admission in PCI-center) of PCI. Following randomisation a strategy of early tenecteplase and additional antiplatelet and antithrombin therapy followed by catheterisation within 2-24 hours with timely coronary intervention as appropriate (or by rescue coronary intervention if required) in Group A will be compared to primary PCI performed according to local standards in Group B.Read full original descriptionShow less
A Randomized Controlled Study of Reperfusion Strategies in Acute ST-segment Elevation Myocardial Infarction Under Conditions of Anticipated In-hospital Delay in Primary Percutaneous Coronary Intervention Strategy: the Reperfusion Approach in Predicted In-hospital Delay for Primary PCI in STEMI (RAPID-STEMI)
This study aims at evaluating of the effectiveness of in-hospital thrombolysis for ST-segment elevation myocardial infarction in PCI centers under conditions of predicted in-hospital delay (>60 min after admission in PCI-center) of PCI. Following randomisation a strategy of early tenecteplase and additional antiplatelet and antithrombin therapy followed by catheterisation within 2-24 hours with timely coronary intervention as appropriate (or by rescue coronary intervention if required) in Group A will be compared to primary PCI performed according to local standards in Group B.
Inclusion: Age equal or greater than 18 years; "Symptom onset-randomization" time interval <12 hours; Predicted "diagnosis-pPCI" time interval equal or greater than 120 minutes; Predicted "admission-pPCI" time interval equal or greater than 60 minutes; Informed consent received.
Exclusion: Medical history, procedures, medication administration or the presence of factors that would in general predispose to bleeding events and/or the inability to evaluate the study primary endpoint.