Using a genetic risk score to find undiagnosed atrial fibrillation
Tests whether a genetic score helps spot hidden atrial fibrillation in adults.
Plain-language title generated from the registry record
Registry title: Prediction of Atrial Fibrillation Using Polygenic Risk Score
Key facts
- Where
- Incheon, Seoul, Suwon, and Uijeongbu-si, South KoreaSee the 5 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 79 years old?
Source: NCT07641582, who can take part
Where in South Korea
- The Catholic University of Korea, Incheon St. Mary's HospitalIncheon, South KoreaTaking people
- The Catholic University of Korea, Eunpyeong St. Mary's HospitalSeoul, South KoreaTaking people
- The Catholic University of Korea, Seoul ST. Mary's HospitalSeoul, South KoreaTaking people
- The Catholic University of Korea St. Vincent's HospitalSuwon, South KoreaTaking people
- The Catholic University of Korea Uijeongbu St. Mary's HospitalUijeongbu-si, South KoreaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Seoul St. Mary's Hospital
- Trial code
- NCT07641582
- Record updated
- 11 June 2026
- Original description
The goal of this clinical trial is to learn whether a genetic risk score can help identify undiagnosed atrial fibrillation (AF) in adults who may have it. AF is an irregular heartbeat that raises the risk of stroke if not treated early.Read full original descriptionShow less
Development of an Atrial Fibrillation Prediction Model Using Polygenic Risk Score: A Prospective Cohort Study
The goal of this clinical trial is to learn whether a genetic risk score can help identify undiagnosed atrial fibrillation (AF) in adults who may have it. AF is an irregular heartbeat that raises the risk of stroke if not treated early.
The main questions it aims to answer are:
Can a polygenic risk score (PRS) - a score based on a person's genes - identify who is more likely to have AF? Does combining PRS with a person's medical history predict AF better than using medical history alone?
Participants will:
Wear a continuous ECG patch for 7 days to record heart rhythm Give a blood sample for genetic testing to calculate their PRS Use a six-lead handheld ECG device (HATIV® P30, VUNO Inc., Seoul, Republic of Korea) to check their own heart rhythm at home once or twice a week for 1 year Visit the clinic 5 times over 1 year
Researchers will use the genetic and clinical information collected to build a scoring system that predicts who is at risk for AF.
Inclusion: Patients with symptoms suggestive of paroxysmal atrial fibrillation, such as intermittent palpitations or chest discomfort; Asymptomatic patients aged 60 or older with at least one of the following risk factors for atrial fibrillation: hypertension, diabetes, coronary artery disease, valvular heart disease, cardiomyopathy, sleep apnea, hyperthyroidism, obesity (BMI greater than 30), or chronic alcohol dependence (drinking more than 3 times per week).
Exclusion: Previously diagnosed with atrial fibrillation prior to study enrollment; Moderate or severe cognitive impairment; Age under 20 years or over 80 years; Does not consent to participate in the study.