Lidocaine Through a Stomach Tube to Reduce Nausea After Weight-Loss Surgery
Tests lidocaine given through a stomach tube against nausea after sleeve gastrectomy.
Plain-language title generated from the registry record
Registry title: Effect of Lidocaine Through Gastric Tube on PONV
Key facts
- Where
- Yinchuan, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07643298, who can take part
Where in China
- General Hospital of Ningxia Medical UniversityYinchuan, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- General Hospital of Ningxia Medical University
- Trial code
- NCT07643298
- Record updated
- 11 June 2026
- Original description
The goal of this clinical trial is to learn if intragastric administration of lidocaine can reduce postoperative nausea and vomiting in obese patients undergoing laparoscopic sleeve gastrectomy. The main question it aims to answer is:Read full original descriptionShow less
Effect of Lidocaine Applied Via Nasogastric Tube on Postoperative Nausea and Vomiting in Obese Patients Undergoing Bariatric Surgery
The goal of this clinical trial is to learn if intragastric administration of lidocaine can reduce postoperative nausea and vomiting in obese patients undergoing laparoscopic sleeve gastrectomy. The main question it aims to answer is:
Does administering 0.5% lidocaine via an orogastric tube reduce the incidence of postoperative nausea and vomiting (PONV) in the post-anesthesia care unit and within the first 24 hours after surgery compared to a placebo (normal saline)?
Researchers will compare the Lidocaine Group to the Placebo Group to see if the intervention lowers the PONV incidence.
Participants will:
* Receive the assigned study solution (either 0.5% lidocaine 20ml or normal saline 20ml) through an orogastric tube upon surgery completion and before extubation. * Have their gastric tube clamped for 5 minutes to ensure mucosal exposure before removal. * Undergo standardized total intravenous anesthesia and perioperative management according to the study protocol. * Be assessed for nausea, vomiting, and other outcomes at specified time points postoperatively in the recovery room and at 6, 12, and 24 hours.
Inclusion: Adults aged between 18 and 65 years old; American Society of Anesthesiologists (ASA) physical status classification II - III; Planned to undergo primary elective laparoscopic sleeve gastrectomy with general anesthesia; Capable of giving informed consent.
Exclusion: History of epilepsy, cardiac conduction abnormalities or previous diagnosis of malignant hyperthermia; Patients who received systemic lidocaine treatment during the operation; Emergency or revision bariatric surgery; Known allergy, hypersensitivity or contraindication to lidocaine or amide - type local anesthetics; History of severe postoperative nausea and vomiting (PONV) or motion sickness, requiring multiple prophylactic medications; Previous significant liver or kidney dysfunction (e.g., ALT/AST > 3 times the upper limit of normal, GFR < 30 mL/min); Pregnancy or lactation.