Vagus nerve stimulation with rehabilitation to improve walking after ischemic stroke
Tests vagus nerve stimulation alongside rehabilitation for leg function after ischemic stroke.
Plain-language title generated from the registry record
Registry title: Impact of VNS With Rehab on Gait Post-Stroke
Key facts
- Where
- Buffalo, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 22 and 80 years old?
Source: NCT07643337, who can take part
Where in United States
- University at Buffalo NeurosurgeryBuffalo, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- State University of New York at Buffalo
- Trial code
- NCT07643337
- Record updated
- 11 June 2026
- Original description
This is a prospective, double-blinded, randomized controlled study to evaluate the impact of Vagus Nerve Stimulation (VNS) therapy on lower limb function.Read full original descriptionShow less
The Impact of Vagus Nerve Stimulation Paired With Rehabilitation on Lower Limb and Gait Functions After Ischemic Stroke
This is a prospective, double-blinded, randomized controlled study to evaluate the impact of Vagus Nerve Stimulation (VNS) therapy on lower limb function.
Inclusion: Approved for Vagus Nerve Stimulation (VNS) and rehabilitation therapy; ≥22 years and ≤ 80 years; Only patients who elect to undergo VNS therapy for stroke-related upper limb deficits; Residual active movement in the affected limb's thumb and other 2 fingers; Stroke-related deficits in the lower limbs and gait with a Functional Ambulation Category (FAC) ≥3; Able to follow simple instructions and independently walk short distances with or without external support or leg orthoses, but without manual contact with another person.
Exclusion: Not a candidate for VNS therapy according to FDA guidelines; Intact lower limb functions (Fugl-Meyer score=34); Pregnant patients.