Gentamicin and Lactobacillus rhamnosus GG instilled in the bladder after spinal cord injury
Tests gentamicin with Lactobacillus rhamnosus GG in the bladder in adults with neurogenic bladder.
Plain-language title generated from the registry record
Registry title: Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD
Key facts
- Where
- Pittsburgh and Washington D.C., United StatesSee the 2 sites
- Phase
- Early phase 1
Where in United States
- University of Pittsburgh Medical CenterPittsburgh, United StatesNo longer taking part
- MedStar National Rehabilitation HospitalWashington D.C., United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medstar Health Research Institute
- Trial code
- NCT07643974
- Record updated
- 21 August 2026
- Original description
The main objective of the proposed research study is to determine in men and women with spinal cord injury/disease and neurogenic bladder whether the dose of coupled gentamicin \& Lactobacillus rhamnosus GG affects the recolonization of the bladder, and whether the rate of success differs by sex. Secondary objectives include determining whether that recolonization lasts 7, 14, or 28 days; and safety of the coupled gentamicin \& Lactobacillus instillations.Read full original descriptionShow less
Effect of Dose Timing of Coupled Intravesical Gentamicin and Lactobacillus Rhamnosus LGG on Success and Length of Colonization in Men and Women With SCI/D and NLUTD
The main objective of the proposed research study is to determine in men and women with spinal cord injury/disease and neurogenic bladder whether the dose of coupled gentamicin \& Lactobacillus rhamnosus GG affects the recolonization of the bladder, and whether the rate of success differs by sex. Secondary objectives include determining whether that recolonization lasts 7, 14, or 28 days; and safety of the coupled gentamicin \& Lactobacillus instillations.
Inclusion: Neurologic diagnosis; ≥18 years old; Neurogenic bladder for at least 6 months; No USQNB-IC A, B1, or B2 symptoms; No currently diagnosed UTI (within 24 hours of initiating instillations); Community dwelling (not in acute hospital setting).
Exclusion: Psychologic or psychiatric conditions influencing the ability to follow instructions; Allergy to ampicillin, daptomycin, gentamicin/gentamycin, or probiotics; Known genitourinary pathology beyond NLUTD (i.e. kidney stones, bladder stones, vesicoureteral reflux, etc.); Use of prophylactic antibiotics or any antibiotics within 2 weeks of beginning instillations; Instillation of intravesical agents other than saline bladder wash; Immunodeficiency; Participation in another study which could confound results.