Following Chinese patients with multiple system atrophy over time
Observes how multiple system atrophy, a rare brain disease, changes in adults in China.
Plain-language title generated from the registry record
Registry title: Prospective Multicenter Registry Study of Multiple System Atrophy in China
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 75 years old?
Source: NCT07644013, who can take part
Where in China
- Peking University First HospitalBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Peking University First Hospital
- Trial code
- NCT07644013
- Record updated
- 12 June 2026
- Original description
Multiple system atrophy is a rare, rapidly progressive neurodegenerative disease characterized by variable combinations of parkinsonism, cerebellar ataxia, and autonomic dysfunction. Existing natural history studies from North America, Europe, and Japan suggest that clinical phenotypes and disease progression may differ across populations. However, comprehensive multicenter prospective data from Chinese patients with multiple system atrophy remain limited.Read full original descriptionShow less
Clinical Features and Natural History of Multiple System Atrophy: A Prospective Multicenter Registry Study in China
Multiple system atrophy is a rare, rapidly progressive neurodegenerative disease characterized by variable combinations of parkinsonism, cerebellar ataxia, and autonomic dysfunction. Existing natural history studies from North America, Europe, and Japan suggest that clinical phenotypes and disease progression may differ across populations. However, comprehensive multicenter prospective data from Chinese patients with multiple system atrophy remain limited.
This prospective multicenter registry study aims to describe the clinical characteristics, longitudinal progression, and outcomes of Chinese patients with multiple system atrophy, to identify factors associated with disease progression and prognosis, and to establish a longitudinal cohort for future biomarker validation and clinical trial design.
Inclusion: Patients with clinically established or clinically probable multiple system atrophy according to the 2022 Movement Disorder Society diagnostic criteria; or; Patients with clinically established or clinically probable Parkinson disease according to the Movement Disorder Society diagnostic criteria; or; Healthy controls or controls without hereditary or neurodegenerative diseases who voluntarily agree to participate; Age between 40 and 75 years; Ability to provide informed consent or availability of a legally authorized representative when applicable.
Exclusion: Secondary parkinsonism due to intracranial space-occupying lesions, normal pressure hydrocephalus, drug-induced parkinsonism, or other identifiable causes; Parkinsonism that cannot be classified as Parkinson disease or multiple system atrophy at the time of evaluation; Clinical suspicion or diagnosis of other atypical parkinsonian syndromes, including progressive supranuclear palsy, dementia with Lewy bodies, or corticobasal syndrome; Comorbid diseases that may substantially affect autonomic function, such as diabetic peripheral neuropathy or amyloidosis; Refusal to participate in the study or refusal to undergo routine clinical evaluations for parkinsonian syndromes; Psychiatric or behavioral abnormalities that preclude reliable clinical data collection or scale-based assessment.