Feasibility and Effects of Noninvasive Brain Stimulation on Pain Perception in People With Fibromyalgia
Key facts
- Where
- Pittsburgh, United StatesSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07644221, who can take part
Where in United States
- Carnegie Mellon UniversityPittsburgh, United StatesContact: Pulkit Grover, PhDNot yet recruiting
- UPMC Pain ManagementPittsburgh, United StatesContact: Benedict J Alter, MD, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Pulkit Grover
- Trial code
- NCT07644221
- Record updated
- 21 October 2026
- Original description
The goal of this interventional study is to learn whether noninvasive brain stimulation (NIBS) will have an effect on pain perception in people with fibromyalgia. The main questions it aims to answer are:Read full original descriptionShow less
Transcranial Electrical Stimulation for Noninvasive Study of Pain Circuits in Patients With Chronic Pain
The goal of this interventional study is to learn whether noninvasive brain stimulation (NIBS) will have an effect on pain perception in people with fibromyalgia. The main questions it aims to answer are:
Do repeated sessions of NIBS lead to a reduction in perceived pain? Do repeated sessions of NIBS lead to an improvement in quality of life?
Researchers will compare different brain targets to see if effects are different between them.
Participants will receive repeated daily sessions of NIBS over 4 weeks with application of pressure pain algometry, and complete various questionnaires.
Inclusion: Formal diagnosis of fibromyalgia made by a practicing physician; Pain resistant to common analgesics and medications for chronic pain; Existing pain for more than 3 months with an average of at least 4 on a 0 to 10 Numerical Rating Scale (NRS); Females of child bearing potential must be at least one of the following totally abstinent from heterosexual intercourse since the last menses before start of study, or agree to concurrent use of at least two methods of birth control throughout study participation.
Exclusion: Subject must not have a history of brain surgery or uncontrolled neurological conditions, such as seizure, fainting spells, transient ischemic attack; Subject must not have lifetime history of severe, uncontrolled mood disorders (anxiety, depression, bipolar), psychotic disorders, other neural disorders, or heart disease; Subject must not have heart diseases, including known arrhythmia, or severe liver or severe gastrointestinal disease or chronic severe infectious disease (e.g. HIV/AIDS); If the subject is non-ambulatory; If the subject is female of child-bearing potential, subject must not be pregnant; Subject must not have any implanted electronic or metallic devices.