Studying fats and tiny blood particles in autoimmune hepatitis compared with fatty liver disease
Compares blood fat patterns in adults with autoimmune hepatitis and fatty liver disease.
Plain-language title generated from the registry record
Registry title: Molecular Characterization of Autoimmune Hepatitis: A Lipidomic Approach
Key facts
- Where
- Castellana Grotte, ItalySee the site
Where in Italy
- IRCCS "S. de Bellis" - Nutritional Biochemistry LabCastellana Grotte, ItalyNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
- Trial code
- NCT07644936
- Record updated
- 15 July 2026
- Original description
This is a two-arm, prospective, controlled observational pilot clinical study aimed at characterizing the lipidomic profile and extracellular vesicles (EVs) of patients with autoimmune hepatitis (AIH) compared to patients with non-alcoholic fatty liver disease (NAFLD). A total of 24 adult outpatients will be enrolled at the Hepatology Outpatient Unit of IRCCS "S. de Bellis". Blood samples will be collected by venipuncture to perform lipidomic analyses on red blood cell membranes and serum, and to isolate and characterize EVs. No intervention beyond standard clinical practice will be appliedRead full original descriptionShow less
Molecular Characterization of Autoimmune Hepatitis Through Lipidomic Analysis and Extracellular Vesicle Profiling: A Controlled Pilot Clinical Study
This is a two-arm, prospective, controlled observational pilot clinical study aimed at characterizing the lipidomic profile and extracellular vesicles (EVs) of patients with autoimmune hepatitis (AIH) compared to patients with non-alcoholic fatty liver disease (NAFLD). A total of 24 adult outpatients will be enrolled at the Hepatology Outpatient Unit of IRCCS "S. de Bellis". Blood samples will be collected by venipuncture to perform lipidomic analyses on red blood cell membranes and serum, and to isolate and characterize EVs. No intervention beyond standard clinical practice will be applied
Inclusion: ARM A:; Confirmed diagnosis of autoimmune hepatitis (AIH); Adult age (≥18 years); Ability to provide written informed consent; Attending the Hepatology Outpatient Unit of IRCCS "S. de Bellis"; ARM B:.
Exclusion: Confirmed diagnosis of non-alcoholic fatty liver disease (NAFLD); Active oncological diseases; Viral hepatitis (HBV, HCV, HIV infection); Severe medical conditions that may compromise study participation; Adult age (≥18 years); Ability to provide written informed consent; Attending the Hepatology Outpatient Unit of IRCCS "S. de Bellis"; Esclusion Criteria:; Liver cirrhosis.