Tests brain stimulation guided by brain scans after ischemic stroke
Tests personalized brain stimulation with a sham procedure in adults after acute ischemic stroke.
Plain-language title generated from the registry record
Registry title: A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
Key facts
- Where
- Beijing, ChinaSee the site
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07645586, who can take part
Where in China
- Beijing Tiantan HospitalBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Beijing Tiantan Hospital
- Trial code
- NCT07645586
- Record updated
- 18 August 2026
- Original description
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke. The treatment uses each participant's brain imaging to identify individualized stimulation targets related to stroke symptoms. Participants will receive either active cTBS or a sham procedure in addition to standard stroke care. The study will assess whether this personalized brain stimulation approach improves functional recovery and is safe for patients after ischemic stroke.Read full original descriptionShow less
Lesion Network Mapping-Navigated Continuous Theta-Burst Stimulation for Motor Recovery in Acute Ischemic Stroke: A Randomized, Double-Blind, Sham-Controlled, Multicentre Phase 3 Trial: MASTRE-3
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke. The treatment uses each participant's brain imaging to identify individualized stimulation targets related to stroke symptoms. Participants will receive either active cTBS or a sham procedure in addition to standard stroke care. The study will assess whether this personalized brain stimulation approach improves functional recovery and is safe for patients after ischemic stroke.
Inclusion: Age 18-80 years; Ischemic stroke onset within the past 14 days; Unilateral, supratentorial ischemic stroke confirmed by CT or MRI; Pre-stroke modified Rankin Scale (mRS) score of 0-1; NIH Stroke Scale (NIHSS) total score 6-25, with item 1a ≤ 1 point, and at least one of items 5a, 5b, 6a, or 6b ≥ 2 points; Written informed consent signed by the patient or the patient's legally authorized representative.
Exclusion: Concomitant malignant tumor or severe systemic disease with life expectancy < 90 days; Participation in any other interventional clinical study within 30 days before randomization, or currently enrolled in such a study; Contraindications to TMS (e.g. cranial metallic foreign bodies, cardiac pacemaker, implanted drug pump, cochlear implant); History of epilepsy or seizure, intracranial hypertension, tumor, or other serious neurological disease; Evidence of acute intracranial hemorrhage, including spontaneous intracerebral hemorrhage, epidural hematoma, subdural hematoma, intraventricular hemorrhage, or subarachnoid hemorrhage; Pre-stroke mRS ≥ 2; Severe psychiatric disorders or dementia (or other conditions) precluding informed consent or follow-up; Midline shift or parenchymal mass effect on cranial CT or other imaging; CT or MRI evidence of bilateral acute cerebral infarction or infratentorial acute infarction (brainstem or cerebellum); Systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg despite antihypertensive treatment; Pregnant or breastfeeding women, or women planning pregnancy within 90 days.