MRI scans to detect bone and muscle loss in people with chronic kidney disease
Tests MRI-FF scans for finding osteoporosis and sarcopenia in adults with chronic kidney disease.
Plain-language title generated from the registry record
Registry title: Clinical Study on a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Chronic Kidney Disease Patients Based on MRI-FF
Key facts
- Where
- Beijing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with chronic kidney disease and for adults without kidney disease as a comparison group. Everyone has MRI scans of the lower back and thigh.
- Age
- 18 to 80 years
- Sex
- All sexes can join.
- Disease stage
- Kidney disease group: chronic kidney disease confirmed by eGFR below 60 mL/min/1.73m² for at least 3 months. Comparison group: no history of chronic kidney disease and normal kidney function.
- Earlier treatment
- People currently using anti-osteoporotic drugs, such as bisphosphonates or teriparatide, cannot join.
Main reasons for not taking part
- Reasons not to have an MRI, such as a pacemaker, metal implants or severe claustrophobia
- Bone metabolic disorder not related to kidney disease, such as osteoporosis or hyperparathyroidism
- Current use of anti-osteoporotic drugs
- Severe lower limb deformity or amputation that affects thigh muscle assessment
- Cannot cooperate with the scan because of cognitive impairment or severe illness
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07645794, who can take part
Where in China
- Nephrology Department of Beijing Jishuitan HospitalBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Capital Medical University
- Trial code
- NCT07645794
- Record updated
- 23 September 2026
- Original description
This is a single-center, observational cohort study aiming to validate the diagnostic value of MRI-FF in identifying osteoporosis and sarcopenia in patients with chronic kidney disease (CKD). A total of 868 participants, including 434 CKD patients and 434 non-CKD controls, will be enrolled at Beijing Jishuitan Hospital. All subjects will undergo MRI-FF scans of the lumbar spine and thigh to assess bone mineral density and muscle fat fraction. The primary objective is to evaluate the correlation between MRI-FF parameters and conventional diagnostic criteria for osteoporosis and sarcopenia, as well as to determine the optimal cut-off values for early detection. The study duration is from March 2026 to December 2028.Read full original descriptionShow less
A Clinical Study on Establishing a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Patients With Chronic Kidney Disease Based on MRI-FFR
This is a single-center, observational cohort study aiming to validate the diagnostic value of MRI-FF in identifying osteoporosis and sarcopenia in patients with chronic kidney disease (CKD). A total of 868 participants, including 434 CKD patients and 434 non-CKD controls, will be enrolled at Beijing Jishuitan Hospital. All subjects will undergo MRI-FF scans of the lumbar spine and thigh to assess bone mineral density and muscle fat fraction. The primary objective is to evaluate the correlation between MRI-FF parameters and conventional diagnostic criteria for osteoporosis and sarcopenia, as well as to determine the optimal cut-off values for early detection. The study duration is from March 2026 to December 2028.
Inclusion: Age between 18 and 80 years old; Able to understand and sign the informed consent form; Able to complete MRI-FF scans of the lumbar spine and thigh; For CKD group: Confirmed diagnosis of chronic kidney disease (eGFR < 60 mL/min/1.73m² for ≥3 months); For control group: No history of chronic kidney disease and normal renal function.
Exclusion: Contraindications to MRI (e.g., pacemaker, metal implants, severe claustrophobia); Current use of anti-osteoporotic drugs (e.g., bisphosphonates, teriparatide); History of primary bone metabolic disorders (e.g., osteoporosis, hyperparathyroidism) unrelated to CKD; Inability to cooperate with the scan due to cognitive impairment or severe illness; Severe lower limb deformity or amputation affecting thigh muscle assessment.