MRI scans to detect bone and muscle loss in people with chronic kidney disease
Tests MRI-FF scans for finding osteoporosis and sarcopenia in adults with chronic kidney disease.
Plain-language title generated from the registry record
Registry title: Clinical Study on a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Chronic Kidney Disease Patients Based on MRI-FF
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07645794, who can take part
Where in China
- Nephrology Department of Beijing Jishuitan HospitalBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Capital Medical University
- Trial code
- NCT07645794
- Record updated
- 23 September 2026
- Original description
This is a single-center, observational cohort study aiming to validate the diagnostic value of MRI-FF in identifying osteoporosis and sarcopenia in patients with chronic kidney disease (CKD). A total of 868 participants, including 434 CKD patients and 434 non-CKD controls, will be enrolled at Beijing Jishuitan Hospital. All subjects will undergo MRI-FF scans of the lumbar spine and thigh to assess bone mineral density and muscle fat fraction. The primary objective is to evaluate the correlation between MRI-FF parameters and conventional diagnostic criteria for osteoporosis and sarcopenia, as well as to determine the optimal cut-off values for early detection. The study duration is from March 2026 to December 2028.Read full original descriptionShow less
A Clinical Study on Establishing a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Patients With Chronic Kidney Disease Based on MRI-FFR
This is a single-center, observational cohort study aiming to validate the diagnostic value of MRI-FF in identifying osteoporosis and sarcopenia in patients with chronic kidney disease (CKD). A total of 868 participants, including 434 CKD patients and 434 non-CKD controls, will be enrolled at Beijing Jishuitan Hospital. All subjects will undergo MRI-FF scans of the lumbar spine and thigh to assess bone mineral density and muscle fat fraction. The primary objective is to evaluate the correlation between MRI-FF parameters and conventional diagnostic criteria for osteoporosis and sarcopenia, as well as to determine the optimal cut-off values for early detection. The study duration is from March 2026 to December 2028.
Inclusion: Age between 18 and 80 years old; Able to understand and sign the informed consent form; Able to complete MRI-FF scans of the lumbar spine and thigh; For CKD group: Confirmed diagnosis of chronic kidney disease (eGFR < 60 mL/min/1.73m² for ≥3 months); For control group: No history of chronic kidney disease and normal renal function.
Exclusion: Contraindications to MRI (e.g., pacemaker, metal implants, severe claustrophobia); Current use of anti-osteoporotic drugs (e.g., bisphosphonates, teriparatide); History of primary bone metabolic disorders (e.g., osteoporosis, hyperparathyroidism) unrelated to CKD; Inability to cooperate with the scan due to cognitive impairment or severe illness; Severe lower limb deformity or amputation affecting thigh muscle assessment.