Studies breathlessness in people with lung diseases and healthy volunteers

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with a known lung disease who feel breathless, and for healthy adults without a limiting condition as a comparison group.

Age

18 to 100 years

Sex

All sexes

Disease stage

A known respiratory diagnosis such as COPD, asthma, bronchiectasis or ILD, with ongoing breathlessness of 2 or more on the MRC dyspnoea scale. Healthy controls must have no limiting lung, heart or muscle and joint condition.

Main reasons for not taking part

• Unstable disease or tests ongoing for unexplained symptoms
• Surgery within the past six weeks
• Reasons not to exercise under ACSM guidelines, such as unstable heart disease or high blood pressure
• BMI of 35 kg/m2 or more
• Cannot communicate in English, cannot give written consent, or cannot stop smoking 8 hours before testing

The registry criteria, word for word

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

• Are you between 18 and 100 years old?YesNo

What the trial wants to find out

Breathlessness is a complex symptom that results in poor quality of life, increased hospitalisations and increased mortality. Breathlessness is influenced by physiological, psychological and functional factors but these are poorly explored. There are also unexplored phenomenon's such as breathing pattern. Therefore, this study aims to understand the influences of physiology, psychology, function and breathing pattern on health related quality of life in those with a respiratory disease compared to healthy controls. This project is a cross-sectional cohort study including those with a known respiratory disease and experiencing breathlessness, compared to non-breathless healthy controls. The investigators will measure your physiology through spirometry (a breathing test that tells us about their lung function), psychology through questionnaires, function through an exercise test and breathing pattern using opto-electrictronic plethysmography (markers are placed on your chest to see how participants breathe while exercising). This will be conducted over two visits. The investigators will recruit participants from clinics at the University Hospitals of Leicester NHS Trust. The investigators are aiming to recruit 50 participants with a respiratory disease and 25 healthy controls. The results of this study will help us understand breathlessness in more detail in order to be able to develop better treatments.

The group in the trial

• 50 participants with a respiratory disease and 25 health controls will be recruited.

  Inclusion criteria is: * Aged 18 or over up to 100 * Known respiratory diagnosis\* OR Healthy control\*\* * Ongoing symptoms of breathlessness defined as ≥2 MRC dyspnoea scale * Able to communicate in English * Able to attend two study visits * Able to provide written informed consent * Known respiratory diagnosis could include, but is not limited to, Chronic Obstructive Pulmonary Disease, Asthma,Bronchiectasis or Interstitial Lung Disease. * Healthy controls are required to have an absence of a functionally limiting condition such as respiratory, cardiovascular, or musculoskeletal. Participants are excluded if,: * Unstable disease or undergoing investigations for unexplained symptoms * Undergone a surgery within past six weeks * Contraindications for exercise outlined by American College of Sports Medicine guidelines (Unstable Cardiovascular disease, hypertension etc) * Body Mass Index ≥ 35kg/m2 * Unable to communicate in English * Unable to provide consent