NCT07650188Recruiting
Stimulating the Aging Brain Using Brain and Sensory Stimulation
Stimulating the Aging Brain: Noninvasive Brain and Sensory Stimulation Strategies in Aging
Source: ClinicalTrials.gov · Last updated 16 Jun 2026
Brief summary (registry, in English)
The goal of this project is to investigate whether transcranial electrical stimulation and sensory stimulation affect language outcomes in individuals with primary progressive aphasia (PPA). The main questions it aims to answer are: Does transcranial alternating current stimulation (tACS) affect verbal short-term memory (STM) in individuals with PPA? Does a single session of multisensory stimulation affect verbal STM in individuals with PPA? Researchers will compare active tACS to sham tACS (a fake stimulation condition) to see if active tACS improves verbal STM. Researchers will compare pre-multisensory stimulation to post-stimulation performance to see if multisensory stimulation improves verbal STM. Participants will: Undergo EEG, MRI (anatomical and functional) May complete a cognitive exam Undergo tACS over 3 separate sessions Undergo multisensory stimulation Complete language tasks before, during and/or after stimulation
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 8 Jun 2026
- Start date
- 1 Jun 2026
- Primary completion date
- 30 May 2031
- Lead sponsor
- Medical College of Wisconsin
- Diseases
- Frontotemporal dementia
- NCT number
- NCT07650188
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 1 Jun 2026 to the primary completion date, 30 May 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any other implants near the scalp or in the eye
Other illness
- Evidence of dementia at baseline
- Known history of neoplasm, symptomatic stroke, moderate to severe traumatic brain injury, or other significant neurologic event
- Evidence of severe psychiatric illness (e.g., bipolar disorder, schizophrenia).
- Presence of cardiac stimulators or pacemakers
- History of ongoing or unmanaged seizures
- History of dyslexia or other developmental learning disabilities
Age
- Age \<45 years.
Other
- Contraindications to MRI or stimulation
- Pregnancy
Who the study is looking for
- Clinical exam supports diagnosis of PPA and/or MCI with no report of difficulty functioning in basic or instrumental activities of daily living.
- Completed clinical cognitive exam within 6 months of study baseline visit OR neuropsychological research battery within 6 months of study baseline visit.
Age in the registry: 45 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.