Building computer models of blood sugar responses in type 2 diabetes treated with insulin
Collects meal response data to build computer models of adults with insulin-dependent type 2 diabetes.
Key facts
- Who runs it
- Clinical Nutrition Research Center, Illinois Institute of Technology
- Where
- Chicago, United StatesSee the site
- Trial code
- Registry title
- Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes
- Status
- Recruiting
- People taking part
- 25 people, planned
- Started
- 20 May 2026
- Expected to end
- 20 Mar 2027
- Type of study
- Observational
- Record updated
- 16 June 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18-65 with type 2 diabetes who take insulin. They will have blood tests after a liquid meal and wear glucose and activity trackers.
- Age
- 18-65 years
- Sex
- Men and women
- Disease stage
- Type 2 diabetes treated with insulin, HbA1c ≥ 6.5% (48 mmol/mol) at screening
- Earlier treatment
- Must have been on insulin for at least 6 months before screening
- Biomarker or test result
- HbA1c ≥ 6.5% (48 mmol/mol) at screening
Main reasons for not taking part
- Allergy or intolerance to the study foods
- Hemoglobin below 9.5 g/dL at screening
- Blood pressure above 160/100 mmHg at screening
- Pregnant or planning pregnancy during the study
- Weight change of 5 kg (11 lb) or more in the previous 2 months
The registry criteria, word for word
Show all 17 criteriaShow less
Who can take part
- Men or women, 18-65 years of age
- Diagnosed with insulin-dependent type 2 diabetes mellitus HbA1c ≥ 6.5% at screening
- Current insulin therapy for ≥ 6 months prior to screening
- Nonsmokers (past smokers can be allowed if they have abstained for a minimum of 12 months)
- Judged to be in good health based on medical history (i.e., no clinical evidence of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or hepatic disease)
- Able to provide informed consent
- Able to comply with and perform the procedures requested by the protocol (including dietary restrictions, consumption of study foods, records of food diary, sample collection procedures, and study visit schedule)
Who cannot take part
- Major trauma or a surgical event within 2 months (or longer depending on trauma or event) and after consultation with PI
- Unstable weight: gained or lost weight +/- 5 kg (11 lbs) in previous 2 months
- Men and women with known or suspected intolerance, allergies, or hypersensitivity to study foods
- History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional
- Men and women with low hemoglobin (Hgb) levels below 9.5 g/dL at the screening visit, indicating anemia
- Men and women with blood pressure >160 mmHg (systolic) / 100 mmHg (diastolic) at the screening visit
- Women who are pregnant or planning to become pregnant during the study
- Vegan or other extreme dietary regimens (e.g., Atkins diet, etc.) as judged by the investigator
- Donated blood within the last 3 months
- Unusual working hours i.e., working overnight (e.g. 3rd shift)
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Where in United States
- Illinois Institute of TechnologyChicago, United StatesContact: Chelsea Preiss, MSTaking people
About the trial
What the trial wants to find out
This observational study aims to collect detailed metabolic and physiologic data from adults with insulin-dependent type 2 diabetes mellitus following consumption of a mixed meal tolerance test. Participants will undergo frequent blood sampling over a 4-hour period after consuming a standardized liquid mixed meal to measure glucose, insulin, glucagon, C-peptide, and triglyceride responses. Participants will also use continuous glucose monitoring and wearable physical activity tracking devices during free-living conditions.
Read full original descriptionShow less
The purpose of this study is to develop mathematical models and digital representations ("digital twins") of people with type 2 diabetes mellitus. These models may help researchers better understand metabolic responses to meals, physical activity, and diabetes treatments, and may support future development of personalized diabetes technologies and therapies.
The group in the trial
- Adults With Insulin-Dependent Type 2 Diabetes Mellitus
Adults 18 to 65 years of age with insulin-dependent type 2 diabetes mellitus who will undergo a liquid meal tolerance test with frequent blood sampling over 4 hours following consumption of a standardized liquid meal. Participants will also undergo outpatient continuous glucose monitoring and wearable physical activity tracking during free-living conditions to support mathematical modeling of metabolic and physiologic responses.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Mathematical Modeling of Type 2 Diabetes Mellitus
- Plain-language title
- Building computer models of blood sugar responses in type 2 diabetes treated with insulinGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 13 November 2026.
- Fit questions
- Built from NCT07650682, who can take part
- Record updated
- 16 June 2026