Interaction Between Decidual Cells and NK Cells in Endometriosis
Key facts
- Where
- Suresnes, FranceSee the site
Where in France
- Hopital FochSuresnes, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hopital Foch
- Trial code
- NCT07652593
- Record updated
- 17 June 2026
- Original description
Endometriosis is a chronic gynecological disease characterized by the presence of endometrial-like tissue outside the uterus and is frequently associated with pelvic pain and infertility. Increasing evidence suggests that immune dysfunction may contribute to the development and persistence of the disease.Read full original descriptionShow less
Interaction Between Decidual Cells and Natural Killer Cells in Endometriosis: A Prospective Pilot Case-Control Study
Endometriosis is a chronic gynecological disease characterized by the presence of endometrial-like tissue outside the uterus and is frequently associated with pelvic pain and infertility. Increasing evidence suggests that immune dysfunction may contribute to the development and persistence of the disease.
The purpose of this prospective case-control study is to compare immune cell characteristics in women with deep endometriosis and women without endometriosis during the secretory phase of the menstrual cycle. Participants will undergo collection of clinical data, blood samples, endometrial samples, and vaginal microbiota samples. For participants undergoing clinically indicated pelvic surgery, additional biological samples may be collected during the procedure. The study aims to improve understanding of the immune mechanisms involved in endometriosis and to identify potential biomarkers associated with the disease.
Inclusion: Endometriosis Group; Female participant aged 18 years or older; Confirmed diagnosis of deep endometriosis by imaging or surgery; Pelvic pain and/or severe dysmenorrhea (Visual Analog Scale > 4); Premenopausal; No contraceptive or hormonal treatment during the study menstrual cycle; Affiliated with a health insurance system; Able and willing to provide written informed consent; Control Group; Female participant aged 18 years or older; No diagnosis of endometriosis; Premenopausal; No contraceptive or hormonal treatment during the study menstrual cycle; No chronic pelvic pain or severe dysmenorrhea (Visual Analog Scale < 4); Affiliated with a health insurance system; Able and willing to provide written informed consent.
Exclusion: Concomitant hormonal treatment; Current infection; Active cancer; Active autoimmune disease; Pregnancy; Participant under guardianship or legal protection; Participant deprived of liberty.