Home Exercise of the Unaffected Leg Studied After Severe Stroke
Tests home-based training of the unaffected leg in adults after severe stroke.
Plain-language title generated from the registry record
Registry title: Tele-CE in Severe Stroke
Key facts
- Where
- Chicago, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07652970, who can take part
Where in United States
- Brain Plasticity LabChicago, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Illinois Chicago
- Trial code
- NCT07652970
- Record updated
- 9 October 2026
- Original description
The goal of this clinical trial is to determine the effects of home-based cross-education on lower limb neuroplasticity in severe stroke.Read full original descriptionShow less
Effect of Home-based Cross-education on Lower Limb Neuroplasticity in Severe Stroke
The goal of this clinical trial is to determine the effects of home-based cross-education on lower limb neuroplasticity in severe stroke.
The main questions the investigators aim to answer are:
* What are the effects of home-based cross-education on lower limb neuroplasticity? * What are the effects of home-based cross-education on lower limb function? * Is home-based cross-education feasible to administer and accepted by participants?
Participants will take part in ten home-based, remotely supervised sessions, during which participants will either perform unilateral skill and strength training of the unaffected lower limb (Tele-Cross Education or Tele-CE) or cognitive training and unilateral movements of the unaffected lower limb (Tele-control). Each participant will experience measures of brain and spinal activity and motor function testing before and after both sessions (Tele-CE and Tele-control). Each participant will also be asked to fill out a feedback questionnaire to assess acceptability after intervention sessions (Tele-CE and Tele-control).
Inclusion: Single, monohemispheric stroke; Chronic stroke (> 6 months prior); Severe stroke (Fugl-Meyer Lower Extremity motor scale score < 21 or 6 Minute Walk Test distance < 300m).
Exclusion: Use of anti-spasticity medications; Previous adverse reaction to TMS; Concussion within the prior 6 months; Metal implants in the head or face; Existence of other neurological disorders; Uncontrolled medical conditions (such as uncontrolled hypertension, untreated cardiac disease, or untreated pulmonary disease); Implanted cardiac pacemaker; History of seizures or epilepsy; Use of medications that could alter cortical excitability or increase risk of seizure (e.g., antidepressants, antipsychotics, anxiolytics, anticonvulsants); Skin hypersensitivity at any sites of stimulation, including the scalp, thoracolumbar spine, and peripheral limbs; History of contact dermatitis at any of the sites of stimulation; History of allodynia and/or hyperalgesia; Active skin infection; Deep vein thrombosis; Any other skin or scalp condition that could be aggravated by stimulation; Have brainstem or cerebellar lesions; Mini-Mental State Examiniation score of <21, to ensure participants have the cognitive capacity to consent and can understand instructions both in-person and during remote supervision; Non-English-speaking individuals; Bone, joint or soft tissue injury; Unable to see the tablet and zoom screen; Unable to move non-paretic ankle (< 5 degrees of ankle ROM); Fugl-Meyer Lower Extremity sensory scale score < 6; TMS exclusion criteria; Skull abnormalities or fractures; Unexplained, recurring headaches; Current pregnancy; PNS exclusion criteria; Skin lesions; Implanted electronic, metallic, or highly conductive devices near site of stimulation that cannot be removed without permission from a health professional.