NCT07653555Not yet recruiting
Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP
A Cluster Randomized Controlled Trial To Evaluate The Efficacy Of Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP
Source: ClinicalTrials.gov · Last updated 18 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the effectiveness of two models of cascade testing in identifying at-risk family members of individuals diagnosed with familial hypercholesterolemia (FH).
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 480 (estimated)
- First submitted
- 2 Jun 2026
- Start date
- Oct 2026
- Primary completion date
- Jun 2028
- Lead sponsor
- Mayo Clinic
- Diseases
- Familial hypercholesterolaemia
- NCT number
- NCT07653555
What you commit to
- Study type: Interventional
- Planned participants: 480
- From Oct 2026 to the primary completion date, Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior participation in structured cascade testing.
- Prior participation in structured cascade testing.
Other illness
- Severe cognitive impairment preventing informed consent.
- Relatives:
- Severe cognitive impairment preventing informed consent.
Age
- Insufficient clinical follow-up (\<5 years).
Other
- Index Patients:
- No confirmed FH diagnosis.
- No identifiable or contactable relatives.
Who the study is looking for
- Index Patients:
- Age ≥ 18 years.
- Confirmed FH diagnosis using Dutch Lipid Clinic Network criteria \*or\* genetic confirmation.
- Identified through REP or Tapestry databases.
- Able and willing to provide informed consent.
- At least one eligible first- or second-degree relative.
- Access to and active use of email (computer literacy requirement).
- Relatives:
- First- or second-degree relative of an enrolled index patient.
- Age ≥ 1 year (minors require parental consent + assent).
- Willing to participate and able to complete electronic consent (guardian-assisted if minor).
- Access to and active use of email (guardian).
Age in the registry: 1 year to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.