Bacillus Clausii Versus Multistrain Probiotics for Acute Watery Diarrhea in Children
Key facts
- Where
- Lahore, PakistanSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 1 and 5 years old?
Source: NCT07660367, who can take part
Where in Pakistan
- Children Hospital and Institute of Child Health, LahoreLahore, PakistanContact: Mamoona ferozTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Children Hospital and Institute of Child Health, Lahore
- Trial code
- NCT07660367
- Record updated
- 13 October 2026
- Original description
This randomized controlled trial will compare Bacillus clausii (Enterogermina) and a multistrain probiotic preparation (Ecotec) in children aged 1-5 years with acute watery diarrhea. Participants will receive one of the probiotic treatments along with standard therapy including oral rehydration solution and zinc supplementation. The study will evaluate the duration of diarrhea, stool frequency, and stool consistency.Read full original descriptionShow less
Comparison of Effectiveness of Bacillus Clausii and Multistrain Probiotics (Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Bifidobacterium, Streptococcus Thermophilus) in the Management of Children With Acute Watery Diarrhea: A Randomised Controlled Trial
This randomized controlled trial will compare Bacillus clausii (Enterogermina) and a multistrain probiotic preparation (Ecotec) in children aged 1-5 years with acute watery diarrhea. Participants will receive one of the probiotic treatments along with standard therapy including oral rehydration solution and zinc supplementation. The study will evaluate the duration of diarrhea, stool frequency, and stool consistency.
Inclusion: Patient with Acute watery diarrhea aged 1 year to 5 years; Both genders will be included; Patients whose guardians/ parents will give informed consent will participate in the study; Patients having mild to moderate dehydration will be included in study; Patients having mild to moderate malnutrition will be included in study.
Exclusion: Children with evidence of concurrent systemic infections other than acute diarrhea (e.g. respiratory tract infections, urinary tract infections, measles, meningitis etc); Children who have received antibiotics or zinc within the past 72 hours prior to enrollment, as this may interfere with gut flora and probiotic efficacy; Children who have received probiotics as a treatment for the current episode of diarrhea prior to study enrollment; Children having history of chronic diarrhea; Children having history of blood in stools; Children with known immunodeficiency disorders or undergoing immunosuppressive treatments (e.g., chemotherapy, corticosteroids); Children with known allergies or hypersensitivity to probiotic components used in the study; Children having cholera; Children who needed I/V antibiotics or I/V rehydration after enrollment.