Remifentanil vs Esmolol During Intubation for Cerebral Aneurysm Coil Embolization
Key facts
- Where
- Istanbul, TürkiyeSee the site
Where in Türkiye
- Fatih Sultan Mehmet Training and Research HospitalIstanbul, TürkiyeContact: Arsen Güngör Ay, MDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Fatih Sultan Mehmet Training and Research Hospital
- Trial code
- NCT07660861
- Record updated
- 22 June 2026
- Original description
Endotracheal intubation may cause significant increases in blood pressure, heart rate, and intracranial pressure, particularly in patients undergoing cerebral aneurysm coil embolization. Remifentanil and esmolol are commonly used agents to attenuate these responses during anesthesia induction.Read full original descriptionShow less
Effects of Remifentanil Versus Esmolol on Optic Nerve Sheath Diameter/Eyeball Transverse Diameter Ratio During Endotracheal Intubation in Patients Undergoing Cerebral Aneurysm Coil Embolization: A Randomized Controlled Trial
Endotracheal intubation may cause significant increases in blood pressure, heart rate, and intracranial pressure, particularly in patients undergoing cerebral aneurysm coil embolization. Remifentanil and esmolol are commonly used agents to attenuate these responses during anesthesia induction.
This randomized controlled trial aims to compare the effects of remifentanil and esmolol administered before endotracheal intubation on optic nerve sheath diameter/eyeball transverse diameter ratio (ONSD/ETD), a noninvasive surrogate marker of intracranial pressure, as well as hemodynamic responses in patients undergoing elective cerebral aneurysm coil embolization.
The findings may help identify the most effective strategy for minimizing intubation-related intracranial pressure changes and hemodynamic fluctuations in neurointerventional anesthesia practice.
Inclusion: Age ≥18 years; American Society of Anesthesiologists (ASA) physical status I-III; Scheduled for elective cerebral aneurysm coil embolization under general anesthesia; Planned endotracheal intubation; Ability to provide written informed consent.
Exclusion: Severe cardiac conduction abnormalities or clinically significant arrhythmias; Contraindication or allergy to remifentanil or esmolol; Known orbital disease, ocular trauma, or conditions interfering with optic nerve sheath diameter measurements; Emergency procedures; Hemodynamic instability before induction of anesthesia; Chronic opioid use or opioid dependence; Anticipated difficult airway; Pregnancy; Refusal to participate in the study.