Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis
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- How often do I need to come in, and for how long each time?
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Contact the study team: see the registry record → Contacts and Locations
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- Who runs it
- Tanta University
- Trial code
- NCT07666347
- Record updated
- 25 June 2026
- Original description
This study aims to compare the efficacy of intra-articular injection of Botulinum toxin and hyaluronic acid on pain in knee osteoarthritis.Read full original descriptionShow less
This study aims to compare the efficacy of intra-articular injection of Botulinum toxin and hyaluronic acid on pain in knee osteoarthritis.
Inclusion: Age ≥ 50 years; Both genders; Chronic knee osteoarthritis (KOA) according to American College of Rheumatology criteria for the diagnosis of knee osteoarthritis; Third or fourth grade Kellgren and Lawrence system for classification of osteoarthritis based on radiological data, it is a common method of classifying the severity of osteoarthritis (OA) using five grades according to the following sites and projections.
Exclusion: History of intra-articular injection within the last 6 months,; History of surgery on the knee joint or major trauma to the lower limb causing fracture; Medical conditions affecting the joint or lower extremity function such as severe osteoporosis, rheumatoid arthritis, collagen vascular diseases, and gout; Any contraindication to intra-articular injections for instance immunodeficiency, coagulation defect or anticoagulation therapy taking or skin infection at the site of injection; Hypersensitivity to Botulinum toxin or hyaluronic acid; Body mass index (BMI) more than 40 kg/m2; Diabetic patient.