Repeat Islet Transplantation in Adults With Type 1 Diabetes After an Earlier Transplant Failed
Looks back at repeat islet transplants in adults with type 1 diabetes.
Key facts
- Who runs it
- University Hospital, Montpellier
- Where
- Montpellier, FranceSee the site
- Trial code
- Registry title
- Efficacy of Islet Re-transplantation After Failure of Beta-cell Replacement
- Status
- Recruiting
- People taking part
- 20 people, planned
- Started
- 31 Jul 2025
- Planned end
- 30 Sept 2026
- Type of study
- Observational, 2 groups
- Record updated
- 24 June 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with type 1 diabetes who had a repeat islet transplant after an earlier islet or pancreas transplant stopped working.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Type 1 diabetes where an earlier beta-cell graft failed: no detectable C-peptide and/or severe low blood sugar came back while on insulin.
- Earlier treatment
- Must have had an islet transplant or a pancreas transplant before. The repeat islet transplant must have been done after 2005.
- Biomarker or test result
- Undetectable C-peptide and/or return of severe low blood sugar on insulin therapy, as proof the first graft failed.
Main reasons for not taking part
- Missing or incomplete data, so the main result cannot be assessed
- People who do not meet the inclusion criteria
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Age ≥ 18 years
- Diagnosis of type 1 diabetes
- Prior beta-cell replacement therapy : islet transplantation or pancreas transplantation
- Islet re-transplantation performed after 2005
- Islet re-transplantation performed after documented beta cell graft failure, defined by undetectable C-peptide and/or recurrence of severe hypoglycemia on insulin therapy
- Availability of clinical and biological data required for assessment of study outcomes
Who cannot take part
- Missing or incomplete data preventing assessment of the primary outcome
- Patients who did not meet inclusion criteria
Where in France
- Montpellier University HospitalMontpellier, FranceContact: Orianne OV Villard, MDTaking people
About the trial
What the trial wants to find out
Islet transplantation and pancreas transplantation are established therapeutic options for selected individuals with type 1 diabetes experiencing severe glycemic instability and recurrent hypoglycemia. Although these approaches significantly improve glycemic management and quality of life, long-term graft survival remains limited, with a progressive decline in beta-cell function over time.
Read full original descriptionShow less
The clinical benefit-risk profile of islet re-transplantation after graft failure remains poorly defined, and outcomes following repeat islet transplantation after prior islet graft failure have not been specifically evaluated.
Repeated exposure to multiple donors may increase the risk of alloimmunization, including the development of donor-specific antibodies , which may adversely affect graft survival and limit access to future transplantation.
This multicenter retrospective cohort study aims to evaluate the efficacy and safety of islet re-transplantation in adults with type 1 diabetes after failure of initial beta-cell replacement (islet or pancreas transplantation), with outcomes assessed at 3 months, 1 year, and 5 years.
The 2 groups in the trial
- Initial pancreas transplant
Islet after pancreas transplant failure
- Initial islet transplant
Islet after islet transplant failure
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Efficacy and Safety of Islet Re-transplantation After Failure of Beta-cell Replacement
- Plain-language title
- Repeat Islet Transplantation in Adults With Type 1 Diabetes After an Earlier Transplant FailedGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 24 June 2026