Eating Approaches for Weight Loss in Adults With Type 1 Diabetes and Overweight
Tests 3 eating approaches for weight loss in adults with type 1 diabetes.
Plain-language title generated from the registry record
Registry title: Dietary Approaches for the Management of Overweight and Obesity in Type 1 Diabetes
Key facts
- Where
- Málaga, SpainSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07667504, who can take part
Where in Spain
- Virgen de la Victoria University HospitalMálaga, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
- Trial code
- NCT07667504
- Record updated
- 15 July 2026
- Original description
Although type 1 diabetes (T1D) has traditionally been considered a disease associated with a lean phenotype, it is estimated that up to 2 out of 3 people living with T1D are overweight or obese, factors linked to an increased risk of complications in these patients. The available evidence regarding nutritional strategies for weight loss in T1D is very limited, and clinical trials are needed to determine how to effectively and safely promote weight loss in this population. In recent years, low-carbohydrate diets and several intermittent fasting protocols have demonstrated efficacy in promoting weight loss both in patients with type 2 diabetes and in patients with obesity without diabetes. This study will evaluate the efficacy of moderate carbohydrate restriction, time-restricted eating, and standard calorie restriction for weight loss in adults with T1D and overweight/obesity.Read full original descriptionShow less
Dietary Approaches for the Management of Overweight and Obesity in Type 1 Diabetes: The D1ANA Study
Although type 1 diabetes (T1D) has traditionally been considered a disease associated with a lean phenotype, it is estimated that up to 2 out of 3 people living with T1D are overweight or obese, factors linked to an increased risk of complications in these patients. The available evidence regarding nutritional strategies for weight loss in T1D is very limited, and clinical trials are needed to determine how to effectively and safely promote weight loss in this population. In recent years, low-carbohydrate diets and several intermittent fasting protocols have demonstrated efficacy in promoting weight loss both in patients with type 2 diabetes and in patients with obesity without diabetes. This study will evaluate the efficacy of moderate carbohydrate restriction, time-restricted eating, and standard calorie restriction for weight loss in adults with T1D and overweight/obesity.
Inclusion: T1D treated with intensive insulin therapy (multiple daily insulin injections or continuous subcutaneous insulin infusion systems); HbA1c 6.5-9%; BMI ≥ 25 and ≤ 45 kg/m2; Active prescription and use of CGM; Active prescription for glucagon.
Exclusion: Previous cardiovascular events (acute myocardial infarction or stroke), heart failure, unstable coronary artery disease, chronic kidney disease with estimated glomerular filtration rate ≤ 30 mL/min/m², cirrhosis, or presence of active cancer; Having experienced a change in body weight greater than 5% within the 3 months before screening; Following any form of diet prior to inclusion, carbohydrate restriction, or intermittent fasting; Forms of diabetes other than T1D, or T1D duration < 1 year; Unstable diabetes, episodes of glycemic decompensation (diabetic ketoacidosis) or severe hypoglycemia (level 3) within the past year; History of eating disorders or alcohol abuse; Presence of other conditions that, in the investigator's judgment, may compromise participation in the study; Use of sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, GLP-1/GIP agonists, or other medications that may influence weight loss; Pregnancy, pregnancy planning, or breastfeeding; Planned change in treatment during the study (switching from multiple daily insulin injections to continuous insulin infusion, or vice versa); Inability to follow the dietary recommendations.