Tailored Anti-Inflammatory American Diet for Patients With Crohn's Disease

Prior treatment

• Prior J pouch or diversion
• Crohn's specific complicated disease including active Stenotic (stricturing, B2) disease within the past 12 months, or Internal penetrating (B3) disease, or Draining perianal fistula, or Prior bowel resection
• Patients with concomitant Celiac disease

Other illness

• Recent inflammatory bowel disease (IBD) related hospitalizations in the last 4 weeks
• Clostridium difficile or enteric infections in the last 4 weeks
• Active cancer or conditions limiting their ability to follow a diet (heart failure, end stage renal disease)

Age

• Ages \< 16 and \> 75 years old

Other

• Diagnosis of Ulcerative Colitis (UC).
• Use of probiotics in the last 4 weeks
• Patients following the specific carbohydrate diet or Mediterranean diet or anti-inflammatory diet
• Pregnancy, breastfeeding or planning to become pregnant during study period
• Use of Total Parenteral Nutrition at the time of screening and during the study period
• Other significant or life-threatening co-morbidities
• The need for antibiotic use during the study period
• Adults unable to consent
• Prisoners

• Documented diagnosis with Crohn's Disease from medical records.
• Ages 16-75
• Mild to moderately active CD disease, defined by one of the following criteria:
  • Crohn's disease activity index (CDAI) 150-250 (mild-to-moderate only active disease) AND presence of active inflammation either by: fecal calprotectin \>150mg/dl. or radiologic findings of active ileal and/or colonic disease, or endoscopic findings showing active ileal and/or colonic disease within 4 weeks of baseline
  • -On stable medications for their disease as or 3 months if medication is not listed