Tests HMB supplement before surgery in people with head and neck cancer
Tests HMB nutritional supplement against placebo before surgery in adults with head and neck cancer.
Plain-language title generated from the registry record
Registry title: Impact of HMB Supplementation on Inflammation and Outcomes in Head and Neck Cancer
Key facts
- Where
- Belo Horizonte, BrazilSee the site
Where in Brazil
- School of Medicine, Federal University of Minas GeraisBelo Horizonte, BrazilTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Federal University of Minas Gerais
- Trial code
- NCT07675421
- Record updated
- 30 June 2026
- Original description
Cancer patients undergoing surgery are at high risk of malnutrition due to the effects of the tumor and surgical stress, which can lead to worse clinical outcomes. This study aims to evaluate the impact of beta-hydroxy-beta-methylbutyrate (HMB) supplementation on inflammatory markers and clinical outcomes in patients with malignant tumors of the upper airways and digestive tract undergoing surgery.Read full original descriptionShow less
Impact of Beta Hydroxy Methyl Butyrate (HMB) Supplementation on Inflammatory Markers and Clinical Outcomes in Patients With Head And Neck Cancer
Cancer patients undergoing surgery are at high risk of malnutrition due to the effects of the tumor and surgical stress, which can lead to worse clinical outcomes. This study aims to evaluate the impact of beta-hydroxy-beta-methylbutyrate (HMB) supplementation on inflammatory markers and clinical outcomes in patients with malignant tumors of the upper airways and digestive tract undergoing surgery.
This is a randomized, double-blind clinical trial. Participants will be randomly assigned to one of two groups: intervention (3 g/day of HMB) or control (3 g/day of maltodextrin) for 30 days prior to surgery. Initial assessments will include nutritional status, muscle strength, quadriceps muscle thickness by ultrasound, and laboratory tests. Postoperative clinical outcomes will be monitored through electronic medical records.
Inclusion: Individuals aged 18 years or older; Both sexes (male and female); Patients treated at the outpatient clinic for head and neck carcinoma; Indication for potentially curative tumor resection surgery.
Exclusion: Diagnosis of cancer of the face, skin, paranasal sinuses, or thyroid; Cognitive or intellectual impairment that may hinder proper understanding of the study; Undergoing neoadjuvant or palliative treatment; Refusal to participate or to sign the informed consent form.