A risk score to predict dementia in older people with depression
Tests a risk score for dementia in older Chinese adults with depression.
Key facts
- Who runs it
- Second Affiliated Hospital of Nanchang University
- Where
- Nanchang, ChinaSee the site
- Trial code
- Registry title
- Clinical Risk Score Prediction for Risk of Dementia Among Late-life Population With Depression
- Status
- Recruiting
- People taking part
- 44 people, planned
- Started
- 1 Jun 2006
- Expected to end
- 30 Jun 2030
- Type of study
- Observational, 2 groups
- Treatments tested
- No Intervention: Observational Cohort
- Record updated
- 30 June 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The study looks at older adults with depression to see who later develops dementia. It uses their routine medical records, with no new tests or treatments.
- Age
- 50 years or older
- Sex
- All sexes
- Disease stage
- Depression diagnosed by a clinician and recorded in the electronic medical record, with no dementia at the start.
Main reasons for not taking part
- Any type of dementia recorded at the start
- Dementia diagnosed before depression, or the order cannot be determined
- Other brain or nerve diseases that can cause severe memory problems, such as Parkinson's disease, multiple sclerosis, brain tumor, normal pressure hydrocephalus
- Missing key baseline record data or incomplete follow-up information
- Refusing to take part or withdrawing consent
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Adults aged ≥50 years
- A diagnosis of depression clearly recorded by a clinician in the electronic medical record at baseline (based on structured or unstructured diagnostic documentation formed through routine clinical practice)
- Complete baseline electronic medical record data available, including at least demographic information (age, sex), clinical diagnoses, comorbidities, and medication records
- At least one follow-up record available in the electronic medical record system to enable determination of incident dementia outcomes
- Informed consent provided for the use of routine medical data for this research analysis
Who cannot take part
- Any type of dementia diagnosis recorded in the electronic medical record at baseline (including Alzheimer's disease, vascular dementia, and other types of dementia)
- Medical record documentation indicating that the diagnosis of dementia preceded the diagnosis of depression, or an inability to clearly determine the chronological order of the two diagnoses
- Presence of other neurological diseases at baseline that may independently cause severe cognitive impairment (e.g., Parkinson's disease, multiple sclerosis, brain tumor, normal pressure hydrocephalus)
- Incomplete follow-up information or inability to clearly confirm incident dementia outcomes through the electronic medical record system
- Missing key baseline electronic medical record data that would preclude subsequent risk model analysis
- Refusal to participate in the study or withdrawal of informed consent
Where in China
- Second Affiliated Hospital of Nanchang UniversityNanchang, ChinaContact: Xi-jian DaiTaking people
About the trial
What the trial wants to find out
The goal of this observational study is to learn about the ability of a point risk score prediction model, developed using electronic medical record data, to predict the risk of progression from geriatric depression to dementia in older Chinese adults. The main questions it aims to answer are:
Read full original descriptionShow less
Does a higher point risk score increase the risk of developing dementia in older adults with depression?
What is the accuracy of the point risk score prediction model in identifying individuals at high risk of dementia among older adults with depression?
Participants will receive their usual medical care as they normally would. No new treatments, tests, or procedures will be performed specifically for this study. The research team will collect data from their electronic medical records, including depression diagnoses, dementia diagnoses, comorbidities, medication records, and follow-up information. The point risk score will be calculated based on these routinely collected clinical data.
The 2 groups in the trial
- Dementia Group
Participants who received a first diagnosis of dementia during the follow-up period. No study-specific intervention is administered; all participants receive routine clinical care as usual.
Treatment: No Intervention: Observational Cohort
- Non-Dementia Group
Participants with no diagnosis of dementia during the follow-up period. No study-specific intervention is administered; all participants receive routine clinical care as usual.
Treatment: No Intervention: Observational Cohort
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Development of a Clinical Risk Score Prediction Tool for 5-, 9-, and 13-year Risk of Dementia Among Late-life Population With Depression: a Longitudinal Cohort Study
- Plain-language title
- A risk score to predict dementia in older people with depressionGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 30 June 2026