Tests a single combined pill for blood pressure, cholesterol and diabetes
Tests a combined pill for high blood pressure, high cholesterol and diabetes in adults.
Plain-language title generated from the registry record
Registry title: Polypills Approach for Multiple Cardiovascular Risk Factors
Key facts
- Where
- Chifeng, Jinan, Jinzhou, Kunshan, Panjin, Shenyang, Suzhou, Taizhou, Tieling, Tongliao, and Zhengzhou, ChinaSee the 15 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 75 years old?
Source: NCT07679828, who can take part
Where in China
- Affiliated Hospital of Chifeng UniversityChifeng, ChinaTaking people
- Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan, ChinaNot yet recruiting
- Central Hospital of JinzhouJinzhou, ChinaTaking people
- Kunshan Hospital of Chinese MedicineKunshan, ChinaNot yet recruiting
- Panjin Central HospitalPanjin, ChinaNot yet recruiting
- First Hospital of China Medical UniversityShenyang, ChinaTaking people
- Shengjing Hospital Of China Medical UniversityShenyang, ChinaNot yet recruiting
- Suzhou Wujiang District Hospital of Traditional Chinese MedicineSuzhou, ChinaNot yet recruiting
- The Fifth People's Hospital of Wujiang DistrictSuzhou, ChinaNot yet recruiting
- The Second Affiliated Hospital of Soochow UniversitySuzhou, ChinaNot yet recruiting
- Taixing Second People's HospitalTaizhou, ChinaNot yet recruiting
- Tieling Central HospitalTieling, ChinaTaking people
- Tiemei General Hospital of Liaoning Health Industry GroupTieling, ChinaTaking people
- Tongliao People's HospitalTongliao, ChinaNot yet recruiting
- The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou, ChinaNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- China Medical University, China
- Trial code
- NCT07679828
- Record updated
- 16 September 2026
- Original description
The Polypill Approach for Multiple Cardiovascular Risk Factors (PACIF) trial is a multicenter randomized controlled trial that will test the effectiveness and safety of a fixed-dose combination strategy for the integrated management of hypertension, dyslipidemia, and type 2 diabetes among adults aged 50 to 75 years without prior cardiovascular disease in China. The trial will evaluate whether a fixed-dose combination strategy improves the 10-year cardiovascular disease risk estimated using the PREVENT equations at Phase 1. Participants will be further followed to determine whether the fixed-dose combination strategy reduces major cardiovascular events and improves cognitive outcomes compared with usual care at Phase 2.Read full original descriptionShow less
Polypills Approach for Multiple Cardiovascular Risk Factors (PACIF) : a Multicentre, Open-label, Randomized Controlled Trial
The Polypill Approach for Multiple Cardiovascular Risk Factors (PACIF) trial is a multicenter randomized controlled trial that will test the effectiveness and safety of a fixed-dose combination strategy for the integrated management of hypertension, dyslipidemia, and type 2 diabetes among adults aged 50 to 75 years without prior cardiovascular disease in China. The trial will evaluate whether a fixed-dose combination strategy improves the 10-year cardiovascular disease risk estimated using the PREVENT equations at Phase 1. Participants will be further followed to determine whether the fixed-dose combination strategy reduces major cardiovascular events and improves cognitive outcomes compared with usual care at Phase 2.
Inclusion: Men or women; Age ≥50 years and <75 years; Systolic blood pressure ≥130 mmHg; LDL-C ≥1.8 mmol/L (70 mg/dL); Type 2 diabetes with HbA1c ≥6.5% and <12%; Willing to participate and able to sign informed consent.
Exclusion: Clinical diagnosis of dementia or treatment with medications for dementia; Known secondary cause of hypertension; Type 1 diabetes; Pancreatic insufficiency or diabetes secondary to pancreatitis; History of myocardial infarction, stroke, or heart failure; History of coronary, cerebrovascular, or peripheral arterial revascularization; History of malignancy; Triglycerides ≥5.65 mmol/L (500 mg/dL); Abnormal serum potassium, defined as serum potassium >5.5 mmol/L or <3.5 mmol/L; Life expectancy <3 years; Abnormal kidney function, defined as estimated glomerular filtration rate <30 mL/min/1.73 m² or dialysis; Abnormal liver function, defined as alanine aminotransferase or aspartate aminotransferase >3 times the upper limit of normal; Contraindication to any of the components of the polypill; Currently living with another PACIF participant; Pregnancy, currently trying to become pregnant, or of child-bearing potential and not using birth control; Currently participating in another intervention study; Any factors judged by the clinic team to be likely to limit adherence to interventions.