Laser imaging with AI to diagnose lung tumors during surgery
Compares laser imaging with AI to frozen section diagnosis in people having lung surgery.
Plain-language title generated from the registry record
Registry title: Label-free Femtosecond Laser Imaging Combined With the Fast Lung Artificial Intelligence Model for Rapid Intraoperative Diagnosis of Lung Surgical Specimens: A Multicentre, Prospective, Parallel-workflow, Non-inferiority Study.
Key facts
- Where
- Shanghai, ChinaSee the 5 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults having lung surgery for a lung nodule or suspected lung tumour, where a tissue check is planned during the operation.
- Age
- 18 Years to 90 Years
- Sex
- All sexes can join.
- Disease stage
- A lung nodule, a space-occupying lung lesion, or a suspected lung tumour seen on scans before surgery.
- Earlier treatment
- No earlier treatment against the tumour, such as chemotherapy, radiotherapy, targeted therapy, immunotherapy or other systemic cancer treatment.
Main reasons for not taking part
- Not enough tissue for both routine pathology and the research tests
- Tissue that is badly burned, dead, crushed, contaminated or poorly stored, so imaging cannot be done
- Imaged tissue that cannot be linked to the lesion in the final pathology result
- No final paraffin pathology result available
- Withdrawal of consent
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 90 years old?
Source: NCT07681245, who can take part
Where in China
- Dongfang HospitalShanghai, ChinaNot yet recruiting
- Huadong HospitalShanghai, ChinaTaking people
- Shanghai Chest HospitalShanghai, ChinaTaking people
- Tongji HospitalShanghai, ChinaTaking people
- Tongren HospitalShanghai, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Shanghai Chest Hospital
- Trial code
- NCT07681245
- Record updated
- 26 October 2026
- Original description
This study aims to evaluate whether femtosecond laser imaging combined with FastLung AI model can provide intraoperative diagnostic performance that is non-inferior to standard frozen section diagnosis for pulmonary nodules or suspected pulmonary tumor lesions. Patients scheduled for lung surgery and requiring intraoperative pathological assessment will be prospectively enrolled. After tumor excision, the fresh tumor specimen will be bisected through the central plane. One half will be used for standard frozen section diagnosis, and the mirrored counterpart will be used for femtosecond laser imaging. Both diagnostic results will be compared with the final paraffin-embedded pathological diagnosis as the reference standard. The results of femtosecond laser imaging will not guide intraoperative clinical decision-making.Read full original descriptionShow less
Label-free Femtosecond Laser Imaging Combined With the Fast Lung Artificial Intelligence Model for Rapid Intraoperative Diagnosis of Lung Surgical Specimens: A Multicentre, Prospective, Parallel-workflow, Non-inferiority Study.
This study aims to evaluate whether femtosecond laser imaging combined with FastLung AI model can provide intraoperative diagnostic performance that is non-inferior to standard frozen section diagnosis for pulmonary nodules or suspected pulmonary tumor lesions. Patients scheduled for lung surgery and requiring intraoperative pathological assessment will be prospectively enrolled. After tumor excision, the fresh tumor specimen will be bisected through the central plane. One half will be used for standard frozen section diagnosis, and the mirrored counterpart will be used for femtosecond laser imaging. Both diagnostic results will be compared with the final paraffin-embedded pathological diagnosis as the reference standard. The results of femtosecond laser imaging will not guide intraoperative clinical decision-making.
Inclusion: Preoperative imaging suggests a pulmonary nodule, pulmonary space-occupying lesion, or suspected pulmonary tumor lesion; The participant is scheduled to undergo pulmonary wedge resection, segmentectomy, lobectomy, or other pulmonary surgery; Fresh lung tissue specimens can be obtained intraoperatively for femtosecond laser imaging; Intraoperative frozen section diagnosis is planned to assess the nature of the tumor lesion; Corresponding postoperative paraffin-embedded pathological diagnosis can be obtained; The participant or the participant's legally authorized representative has signed the written informed consent form; Patients had not received any antitumor treatment prior to enrollment or specimen collection, including chemotherapy, radiotherapy, targeted therapy, immunotherapy, or other systemic anticancer treatments.
Exclusion: Other conditions that, in the opinion of the investigator, make the participant unsuitable for this study; The intraoperative specimen is insufficient and cannot simultaneously meet the requirements for routine clinical pathological diagnosis and research-related testing; The specimen shows severe carbonization, necrosis, compression, contamination, or improper preservation, and the investigator determines that effective imaging cannot be completed; The femtosecond laser imaging specimen cannot be matched with the corresponding lesion assessed by final paraffin pathology; Final paraffin-embedded pathological diagnosis cannot be obtained; The participant withdraws informed consent.